Ivermectin and Abamectin

  • William C. Campbell

Table of contents

  1. Front Matter
    Pages i-xx
  2. Part I

    1. M. H. Fisher, H. Mrozik
      Pages 1-23
    2. R. W. Burg, E. O. Stapley
      Pages 24-32
    3. Mary Nallin Omstead, Louis Kaplan, Barry C. Buckland
      Pages 33-54
    4. S. T. Chen, O. D. Hensens, M. D. Schulman
      Pages 55-72
    5. M. J. Turner, J. M. Schaeffer
      Pages 73-88
  3. Part II

    1. George R. Lankas, Lea R. Gordon
      Pages 89-112
    2. David W. Fink, Arturo G. Porras
      Pages 113-130
    3. Shuet-Hing Lee Chiu, Anthony Y. H. Lu
      Pages 131-143
    4. George V. Downing
      Pages 144-148
    5. J. D. Pulliam, J. M. Preston
      Pages 149-161
    6. B. A. Halley, R. J. Nessel, A. Y. H. Lu
      Pages 162-172
    7. P. G. Wislocki, L. S. Grosso, R. A. Dybas
      Pages 182-200
    8. L. S. Grosso, R. A. Dybas, S. F. Rickard
      Pages 201-214
  4. Part III

    1. G. W. Benz, R. A. Roncalli, S. J. Gross
      Pages 215-229
    2. G. W. Benz, J. L. Cox
      Pages 230-233
    3. William C. Campbell, W. H. D. Leaning, R. L. Seward
      Pages 234-244
    4. William C. Campbell
      Pages 245-259
    5. Richard A. Dybas
      Pages 287-310
    6. Bruce M. Greene, Kenneth R. Brown, Hugh R. Taylor
      Pages 311-323
  5. Back Matter
    Pages 324-363

About this book


Ivermectin and abamectin, members of the avermectin family of compounds, were introduced to the market in the 1980's as a veterinary antiparasitic drug and agricultural pesticide, respectively. Their acceptance and commercial success have been remarkable; both are highly effective and in worldwide use. The efficacy of ivermectin in river blindness has expanded the interest in its use in human medicine. In response to the intense scientific and industrial interest in ivermectin and abamectin and the likelihood that they will be forerunners of an expanding family of drugs, this comprehensive monograph satisfies the need for a review and synthesis of current knowledge about the use of these substances in crop protection as well as in cattle, sheep, swine, horses, dogs, cats, birds, fish, reptiles, and in man. This overview presents chemical, biochemical, and microbiological data, as well as pharmacological, safety, and environmental aspects and covers practical use of the compounds as antiparasitic and pesticide agents, as well as the available safety data that have emerged from the clinical experience with human applications.


chemistry crop protection development drug fish kinetics medicine metabolism parasite pesticide pharmacokinetics reptiles toxicology

Editors and affiliations

  • William C. Campbell
    • 1
  1. 1.Merck Institute for Therapeutic ResearchRahwayUSA

Bibliographic information