Endocrine Function and Aging

  • H. James Armbrecht
  • Rodney M. Coe
  • Nirandon Wongsurawat

Table of contents

  1. Front Matter
    Pages i-xxi
  2. Age-Related Changes in Hormone Secretion and Action

  3. Regulation of Carbohydrate Metabolism (Diabetes)

    1. Front Matter
      Pages N3-N3
    2. Dariush Elahi, Barbara Clark, Reubin Andres
      Pages 48-63
  4. Maintenance of Bone Structure (Osteoporosis)

    1. Front Matter
      Pages 65-65
    2. William A. Peck
      Pages 67-78
  5. Maintenance of Reproductive Function (Impotence)

    1. Front Matter
      Pages N5-N5
    2. John E. Morley, Fran E. Kaiser
      Pages 99-114
    3. Ronald C. Strickler
      Pages 115-135
  6. Regulation of Blood Pressure (Hypertension)

    1. Front Matter
      Pages N7-N7
    2. Michael L. Tuck
      Pages 147-160
    3. Harry G. Preuss, Mohmed Zein, Jorge L. Areas, Gao Chun Yun
      Pages 161-174
  7. Adaptation to Stress

    1. Front Matter
      Pages N9-N9
    2. Margie K. Edel
      Pages 186-199
    3. Salman Azhar, Philip Y. Popplewell, Eve Reaven
      Pages 200-217
    4. R. Strong, M. A. Moore, C. Hale, W. J. Burke, H. J. Armbrecht, A. Richardson
      Pages 218-227
  8. Back Matter
    Pages 229-236

About this book


One of the hallmarks of aging is the decreased capacity to adapt to changes in the environment. In a constant, controlled environment, it is often difficult to distin­ guish the functioning of the young organism from that of the old. However, when stresses are applied-temperature stresses, dietary stresses, infection, emotional stresses-the differences are more apparent. Frequently, the response ofthe old is delayed and may never reach the same mag'nitude as the young. These responses, in most cases, are mediated by the neuroendocrine system, which communicates via hormones, neurotransmitters, and related substances. Thus, it is important to understand the age-related changes that take place in the secretion and act ion of these substances and how these changes relate to the well-being of the whole organism. Indeed, the "neuroendocrine theory of aging" proposes that almost all of the characteristics of aging can be accounted for by dysfunction of the neuroendocrine system. A book on endocrine function and aging is particularly relevant at this time. With the advent of the techniques of molecular biology, there has bee~ an explo­ sion of knowledge concerning hormone secretion and action. Hormones, pro­ hormones, hormone receptors, and "second messenger" mediators rapidly are being cloned and sequenced. Such knowledge gives us important insights into the molecular workings of these substances as well as into the genetic hasis of endo­ crine dysfunction. These new tools are now being applied to the problem of age­ related changes in endocrine function.


Diabetes adaptation aging bone hormone metabolism

Editors and affiliations

  • H. James Armbrecht
    • 1
    • 2
    • 3
  • Rodney M. Coe
    • 4
    • 2
    • 1
  • Nirandon Wongsurawat
    • 1
    • 2
  1. 1.Geriatric Research, Education, and Clinical CenterVeterans Administration Medical CenterSt. LouisUSA
  2. 2.Department of Internal MedicineSt. Louis University School of MedicineSt. LouisUSA
  3. 3.Department of BiochemistrySt. Louis University School of MedicineSt. LouisUSA
  4. 4.Department of Community MedicineSt. Louis University School of MedicineSt. LouisUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media New York 1990
  • Publisher Name Springer, New York, NY
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4612-7930-3
  • Online ISBN 978-1-4612-3240-7
  • Buy this book on publisher's site