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The Somatotrophic Axis and the Reproductive Process in Health and Disease

  • Eli Y. Adashi
  • Michael O. Thorner
Conference proceedings

Part of the Serono Symposia USA Norwell, Massachusetts book series (SERONOSYMP)

Table of contents

  1. Front Matter
    Pages i-xviii
  2. Growth Hormone and Its Receptor: State of the Art

    1. Front Matter
      Pages 1-1
    2. M. O. Thorner, M. L. Hartman, C. M. Silva, B. D. Gaylinn, J. A. Aloi, S. E. Kirk et al.
      Pages 3-13
    3. James A. Wells, Anthony A. Kossiakoff
      Pages 14-22
    4. Gerhard Baumann, Moises Mercado, Norma Davila, Melissa Shaw, Klaus Amburn
      Pages 23-27
    5. Daniel I. H. Linzer, Brian J. Arey
      Pages 28-39
  3. Pubertal, Menstrual, Gestational, and Menopausal Adaptation

    1. Front Matter
      Pages 67-67
    2. Alan D. Rogol, Paul M. Martha Jr., Michael Johnson, Johannes D. Veldhuis, Robert M. Blizzard
      Pages 69-82
    3. Claes Ohlsson, Jörgen Isgaard, Anders Lindahl, Olle G. P. Isaksson
      Pages 94-106
    4. W. S. Evans, R. A. Booth Jr., K. K. Y. Ho, A. C. S. Faria, C. M. Asplin, J. D. Veldhuis et al.
      Pages 107-123
    5. Nancy E. Cooke, Beverly K. Jones, Alan Salzman, J. Eric Russell, Anita Misra-Press, Margrit Urbanek et al.
      Pages 124-141
    6. Mark L. Hartman, Jill A. Kanaley, Arthur Weltman
      Pages 142-159
    7. Ken K. Y. Ho, Andrew J. Weissberger, John J. Kelly
      Pages 160-171
  4. Growth Hormone: The Ovarian Connection

    1. Front Matter
      Pages 173-173
    2. James M. Hammond, Susan Samaras, Randall Grimes, Daniel Hagen, David Guthrie
      Pages 183-201
    3. Stephen Franks, Debbie Willis, Diana Hamilton-Fairley, Davinia M. White, Helen D. Mason
      Pages 220-228
  5. Potential Utility of Growth Hormone in Clinical Reproductive Medicine

    1. Front Matter
      Pages 229-229
    2. Peter Sönksen, Andrew J. Weissberger, Katherine Verikiou
      Pages 231-245
    3. E. Kirk Neely, Ron G. Rosenfeld
      Pages 258-268
  6. Potential Utility of Growth Hormone in Ovulation Induction

  7. Back Matter
    Pages 297-308

About these proceedings

Introduction

For many years now, our understanding of the somatotrophic and reproduc­ tive axes has evolved essentially independently, both fields of study reaching a highly advanced, although far from complete, level of under­ standing. Along the way, however, it became apparent that in some circumstances the reproductive and somatotrophic axes may be inter­ dependent. Inklings to this effect were at times feeble and at other times more convincing. Among those inklings are the clinical recognition by pediatric endocrinologists of the apparent association between isolated GH deficiency and delayed puberty, as well as of the apparent permissive, pUberty-promoting property of GH. Equally important is a body of experi­ mental studies establishing the ovary of multiple species as a site of GH reception and action. Arguing against an essential role for GH in the reproductive process is the observation that individuals who have GH resistance of the Laron variety are fertile arid that isolated GH deficiency does not constitute an absolute barrier to the attainment of sexual maturation and fertility. The intraovarian insulin-like growth factor (IGF) hypothesis proposes that IGFs may serve as amplifiers of gonadotropin action. Although the dependence of intraovarian IGFs on systemic GH action has never been unequivocally demonstrated, that leap of faith has often been made. The intraovarian IGF hypothesis serves as the rationale for the adjunctive use of GH in the induction of ovulation.

Keywords

G proteins genes growth factor insulin-like physiology prolactin steroids

Editors and affiliations

  • Eli Y. Adashi
    • 1
  • Michael O. Thorner
    • 2
  1. 1.Division of Reproductive Endocrinology, Department of Obstetrics and GynecologyUniversity of Maryland School of MedicineBaltimoreUSA
  2. 2.Division of Endocrinology and Metabolism, Department of MedicineUniversity of Virginia Health Sciences CenterCharlottesvilleUSA

Bibliographic information