Bovine Spongiform Encephalopathy

The BSE Dilemma

  • Clarence J. GibbsJr.

Part of the Serono Symposia USA Norwell, Massachusetts book series (SERONOSYMP)

Table of contents

  1. Front Matter
    Pages i-xxv
  2. The Potential Risk to Humans of Amyloids in Animals

  3. Host Range and Pathogenesis

    1. Front Matter
      Pages 9-9
    2. Gerald A. H. Wells, Michael Dawson, Stephen A. C. Hawkins, Anthony R. Austin, Robert B. Green, Ian Dexter et al.
      Pages 28-44
  4. Transmission and Pathogenesis of Spongiform Encephalopathies

    1. Front Matter
      Pages 57-57
    2. James L. Hourrigan, Albert L. Klingsporn
      Pages 59-83
    3. Clarence J. Gibbs Jr., Jiri Safar, Michael P. Sulima, Alfred E. Bacote, R. Andres San Martin
      Pages 84-91
    4. Randall C. Cutlip, Janice M. Miller, Richard E. Race, Allen L. Jenny, Howard D. Lehmkuhl, Mark M. Robinson
      Pages 92-96
    5. Richard F. Marsh
      Pages 114-121
    6. A. A. Schudel, B. J. Carrillo, E. L. Weber, J. Blanco Viera, E. J. Gimeno, C. Van Gelderen et al.
      Pages 138-154
  5. Biochemistry: Protein Chemistry, Molecular Biology, and Molecular Genetics of the Spongiform Encephalopathies

    1. Front Matter
      Pages 177-177
    2. Glenn C. Telling, Michael Scott, Stanley B. Prusiner
      Pages 202-231
    3. Richard Rubenstein, Richard J. Kascsak, Carol L. Scalici, Regina Fersko, Adrienne A. Rubenstein, Michael C. Papini et al.
      Pages 232-250
    4. Heino Diringer, Michael Beekes, Elizabeth Baldauf, Sven Cassens, Muhsin Özel
      Pages 251-270
    5. Maurizio Pocchiari, Loredana Ingrosso, Anna Ladogana
      Pages 271-281
  6. Pathogenesis, Molecular Biology and Genetics, and Immunohistochemistry

    1. Front Matter
      Pages 283-283
    2. Peter B. G. M. Belt, Alex Bossers, Bram E. C. Schreuder, Mari A. Smits
      Pages 294-305
    3. Byron Caughey, Suzette Priola, David Kocisko, Gregory Raymond, Jon Come, Santosh Nandan et al.
      Pages 306-316
    4. Mauro Ceroni, Jiri Safar, Pedro Piccardo, Paul P. Liberski, Paola Pergami, Clarence J. Gibbs Jr.
      Pages 338-356
  7. Public Health Considerations of Human and Animal Spongiform Encephalopathies

  8. Back Matter
    Pages 395-414

About this book


The very first international working discussion on slow infections of the nervous system was entitled "Slow, Latent, and Temperate Virus Infec­ tions" and was held at the National Institutes of Health (NIH) in December 1964. The primary impetus was the discovery and investigation of kuru in New Guinea by D. Carleton Gajdusek, M. D. This working discussion brought together investigators in human and veterinary medicine, virolo­ gists, microbiologists, and neuropathologists actively engaged in laboratory work with viruses that illustrated properties of latency, masking, slowness, or temperateness, with emphasis on subacute and chronic neurologic dis­ eases of unknown etiology. In the Preface to the monograph of published papers presented at the working discussion, Gajdusek and Gibbs wrote the following: After microbiology had given solution to the etiology of most acute infections of the central nervous system and after fungi and bacteria had been incriminated in impor­ tant chronic disorders of the nervous system such as torula and tuberculosis men­ ingitis, we have been left, in neurology, with a wide range of subacute and chronic affections of the central nervous systems of unknown etiology. Some of these diseases, still listed as idiopathic, are among the most prevalent afflictions of the central nervous system. Many others with familial patterns of occurrence do not yet have their basic pathogenesis or underlying metabolic defect elucidated, although we tend to think of them as genetically mediated.


BSE biochemistry genetics infection infections molecular biology molecular genetics pathogenesis

Editors and affiliations

  • Clarence J. GibbsJr.
    • 1
  1. 1.Laboratory of Central Nervous System Studies Basic Neurosciences Program Division of Intramural ResearchNational Institute of Neurological Disorders and Stroke National Institutes of HealthBethesdaUSA

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