Genetic Models of Immune and Inflammatory Diseases

  • Abul K. Abbas
  • Richard A. Flavell

Part of the Serono Symposia USA book series (SERONOSYMP)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Autoimmunity

    1. Front Matter
      Pages 1-1
    2. Charles A. Janeway Jr., Florence Susan Wong, Sylvie Guerder, Eva-Pia Reich, Irene Visintin, Richard A. Flavell
      Pages 3-15
    3. Jacques F. A. P. Miller, William R. Heath, Janette Allison
      Pages 16-21
    4. Günter J. Hämmerling, Judith Alferink, Iris Ferber, Andreas Limmer, Bernd Arnold
      Pages 22-28
    5. Joel D. Taurog, Robert E. Hammer
      Pages 44-50
  3. Autoimmunity, Infections

    1. Front Matter
      Pages 69-69
    2. Iqbal S. Grewal, Jianchao Xu, Richard A. Flavell
      Pages 53-68
    3. David Lo
      Pages 69-81
    4. Ruby Quartey Papafio, Don Healey, Lorraine O’reilly, Patricia Hutchings, Sue Day, Anne Cooke
      Pages 82-88
  4. Cytokines, Co-Stimulators, Tumor Immunity

    1. Front Matter
      Pages 117-117
    2. Michael P. Sethna, Luk Van Parijs, Arlene H. Sharpe, Gordon J. Freeman, Abul K. Abbas
      Pages 101-106
    3. Frank Borriello, Elizabeth A. Tivol, Gordon J. Freeman, Arlene H. Sharpe
      Pages 107-120
    4. Myung-Shik Lee, Nora Sarvetnick
      Pages 121-128
  5. Cytokine Deletions

    1. Front Matter
      Pages 147-147
    2. Alexander Kratz, Donna M. Barten, Antonio Campos-Neto, Nancy H. Ruddle
      Pages 149-153
    3. Xiaojian Huang, Bruce Hultgren, Sharon Pitts-Meek, Jim Hully, Jim Maclachlan, Noel Dybdal et al.
      Pages 154-166
    4. Werner Müller
      Pages 167-169
  6. Back Matter
    Pages 171-179

About this book


This book contains the proceedings of the Serono Symposia USA interna­ tional symposium on Genetic Models of Immune and Inflammatory Dis­ eases held on October 20 to 23, 1994, in Savannah, Georgia. The advent of methods for introducing genes into the germlines of mice, and for targeted disruption of particular genes by homologous recombination, has provided scientists in many disciplines with an extraordinarily powerful set of analyti­ cal tools. Some of the most informative applications of transgenic and gene knockout technology have been in studies of lymphocyte development and activation. The goal of this symposium was to bring together investigators using these genetic approaches for analyzing the immune system, with a view to defining common themes and novel directions. Transgenic mice have a wide variety of important applications in immu­ nology. Defined proteins can be expressed in selected tissues throughout development, thus acquiring the essential characteristic of "self" antigens. Such models have been used to study how immune responses to these artificially created "self" antigens are controlled. Antigen receptors of lym­ phocytes have been expressed as transgenes, and because lymphocytes are endowed with the unique property of allelic exclusion, such transgenic mice become essentially monospecific. Immunomodulatory agents have been expressed in defined tissues or throughout the body, providing tools for studying the functional consequences of dysregulated expression of biologi­ cal response modifiers.


Antigen antigen presentation autoimmunity cytokine cytokines diseases infection infections interferon lymphocytes regulation tumor

Editors and affiliations

  • Abul K. Abbas
    • 1
  • Richard A. Flavell
    • 2
  1. 1.Department of PathologyBrigham and Women’s Hospital and Harvard Medical SchoolBostonUSA
  2. 2.Section of ImmunobiologyYale University School of MedicineNew HavenUSA

Bibliographic information