• Rogerio A. Lobo

Part of the Serono Symposia USA book series (SERONOSYMP)

Table of contents

  1. Front Matter
    Pages i-xv
  2. What Is the Perimenopause?

    1. Rogerio A. Lobo
      Pages 1-3
  3. Oocyte Depletion

    1. Front Matter
      Pages 5-5
    2. Robert W. Rebar, Marcelle I. Cedars, James H. Liu
      Pages 7-11
    3. David E. Battaglia
      Pages 21-35
    4. Joe Leigh Simpson
      Pages 36-45
    5. Lawrence C. Layman
      Pages 46-77
    6. Claude L. Hughes, Glinda S. Cooper
      Pages 87-100
    7. Richard T. Scott Jr.
      Pages 119-143
    8. David B. Seifer
      Pages 144-153
  4. Endocrine Changes

    1. Front Matter
      Pages 155-155
    2. Nancy E. Reame
      Pages 157-169
    3. Henry G. Burger
      Pages 170-183
    4. Fredi Kronenberg
      Pages 184-201
    5. Bruce Ettinger
      Pages 202-209
    6. Daniel E. Stein, Nanette Santoro
      Pages 210-232
    7. Ian S. Fraser
      Pages 233-245
    8. Peter J. Schmidt, Catherine A. Roca, David R. Rubinow
      Pages 246-254
    9. M. Lynne Reuss, Jennie Kline, Rosalba Santos, Bruce Levin, Ilan Timor-Tritsch
      Pages 255-261
  5. Treatment Options

  6. Back Matter
    Pages 331-349

About this book


The perimenopause is an extremely important time in a woman's life. In a similar but reverse sequence to puberty, it signals a change in ovarian status. Although some women pass through this transition without symptoms or concern, for many women, the perimenopause, which can last several years, is of great concern. Symptoms of estrogen deficiency, menstrual irregular­ ity, concerns over changes in mood, as well as reproductive concerns lead to anxiety and frustration. Because it is poorly understood, many clinicians are equally frustrated in finding ways to help their patients and question the appropriateness and/or need for treatment. This Serono Symposia USA, Inc., meeting was designed to help address some of these issues from both a basic science and a clinical perspective, and to provide a forum for discussion. The waning of ovarian function can be divided into two events that are dissociated: gametogenic and endocrine failure. Thus, the symposium was divided into three parts to address these two phenomena and to discuss treatment options. An outstanding international group of clinicians and investigators assembled to first address oocyte depletion and possible markers. Next the complex endocrine changes were discussed as well as the physiologic consequences of these changes. This included a discussion of hot flushes, bone and cardiovascular changes, menstrual irregularity, mood disturbances and depression, and anatomical changes in the ovary and breast. The third part of the symposium addressed treatment options, both in terms of symptoms as well as reproductive and fertility concerns.


Gonadotropin cell fertility menopause planning sonography steroid ultrasound

Editors and affiliations

  • Rogerio A. Lobo
    • 1
  1. 1.Department of Obstetrics and Gynecology College of Physicians and SurgeonsColumbia UniversityNew YorkUSA

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