Signal Transduction in Mast Cells and Basophils

  • Ehud Razin
  • Juan Rivera

Table of contents

  1. Front Matter
    Pages i-xx
  2. Section I

    1. Front Matter
      Pages 1-1
    2. Stephen J. Galli, Mindy Tsai, Chris S. Lantz
      Pages 11-30
    3. Guang W. Wong, Daniel S. Friend, Richard L. Stevens
      Pages 39-53
    4. Lixin Li, Xiao-Tong Zhang, Steven A. Krilis
      Pages 54-65
    5. John W. Schrader
      Pages 66-84
    6. Yoseph A. Mekori, Karin Hartmann, Dean D. Metcalfe
      Pages 85-94
  3. Section II

    1. Front Matter
      Pages 95-95
    2. Kenneth A. Field, David Holowka, Barbara Baird
      Pages 102-114
    3. Reuben P. Siraganian, Juan Zhang, Teruaki Kimura
      Pages 115-133
    4. Patrick G. Swann, Sandra Odom, Juan Rivera
      Pages 152-170
  4. Section III

    1. Front Matter
      Pages 179-179
    2. David S. Cissel, Paul F. Fraundorfer, Michael A. Beaven
      Pages 207-226
    3. Michael A. McCloskey
      Pages 227-246
    4. Cheng Zhang, Michael A. Beaven
      Pages 247-273
    5. Toshiaki Kawakami, Libo Yao, Yuko Kawakami
      Pages 274-285
    6. Ronit Sagi-Eisenberg
      Pages 286-299
    7. Anna Koffer, Richard Sullivan
      Pages 300-315
  5. Section IV

    1. Front Matter
      Pages 317-317
    2. Hovav Nechushtan, Ehud Razin
      Pages 323-327
    3. Thomas Baumruker, Eva E. Prieschl
      Pages 328-336
    4. Melanie A. Sherman, Melissa A. Brown
      Pages 337-349
    5. Clifton O. Bingham III, Jonathan P. Arm, K. Frank Austen
      Pages 350-361
    6. Chris Mathes, Francisco Mendez, Andrea Fleig, Reinhold Penner
      Pages 362-371
    7. Donald MacGlashan Jr.
      Pages 372-389
    8. Susan M. MacDonald
      Pages 390-401
  6. Back Matter
    Pages 403-423

About this book


Mast cells and basophils are responsible for inflammatory and allergic reactions. As such, the signals that generate these responses and how their pathways of action work are the focus of much present day research into allergy and inflammation. This book focuses primarily on the molecular mechanisms that govern mast cell and basophil cell biology and function, as well as providing a comprehensive summary of the field of signal transduction and also giving insights into areas that have therapeutic potential. The book provides detailed insights into mast cell and basophil growth and development, their activation by allergens, including details of receptor activation and downstream events, and the regulators of morphology and degranulation. The metabolic pathways involved in prostaglandin and leukotriene production are discussed as is the role of transcription factors in mast cell growth and cytokine production. Written by leaders in the field, this volume will provide the reader with an up-to-date account of a topic where the rapid progress makes conventional information gathering difficult.


Activation apoptosis biology cell cell biology cytokine immunoglobulin membrane metabolism molecular mechanisms morphology protein regulation signal transduction transcription

Editors and affiliations

  • Ehud Razin
    • 1
  • Juan Rivera
    • 2
  1. 1.Department of Biochemistry, Haddasah Medical SchoolHebrew UniversityJerusalemIsrael
  2. 2.Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin DiseasesNational Institutes of HealthBathesdaUSA

Bibliographic information