Gene Therapy and Tissue Engineering in Orthopaedic and Sports Medicine

  • Johnny Huard
  • Freddie H. Fu

Part of the Methods in Bioengineering book series (MB)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Background

    1. Front Matter
      Pages 1-1
    2. Christian Lattermann, Freddie H. Fu
      Pages 3-14
  3. Gene Therapy Applications for the Musculoskeletal System

    1. Front Matter
      Pages 41-41
    2. Jay R. Lieberman
      Pages 43-56
    3. Kotaro Nishida, James D. Kang, Scott D. Boden, Lars G. Gilbertson, Jun-Kyo Suh, Paul D. Robbins et al.
      Pages 57-73
    4. Jacques Ménétrey, Channarong Kasemkijwattana, Charles S. Day, Patrick Bosch, Morey S. Moreland, Freddie H. Fu et al.
      Pages 74-88
    5. Christopher Niyibizi, Patrick N. Smith, Joel Greenberger
      Pages 106-125
  4. Tissue Engineering in Orthopaedics and Sports Medicine

    1. Front Matter
      Pages 141-141
    2. Henry E. Young
      Pages 143-173
    3. Savio L-Y. Woo, Nobuyoshi Watanabe, Kevin A. Hildebrand
      Pages 174-195
    4. Douglas S. Musgrave, Charles S. Day, Patrick Bosch, Jacques Ménétrey, Channarong Kasemkijwatanna, Morey S. Moreland et al.
      Pages 196-212
    5. Jun-Kyo Suh, Freddie H. Fu
      Pages 213-229
  5. Hurdles and Development of New Vectors for Gene Therapy and Tissue Engineering

    1. Front Matter
      Pages 231-231
    2. Jacques P. Tremblay
      Pages 233-244
    3. Paul D. Robbins, Steven C. Ghivizzani, Joseph C. Glorioso, Christopher H. Evans
      Pages 245-259
    4. Xiao Xiao, Ryan Pruchnic, Juan Li, Johnny Huard
      Pages 260-273
  6. Back Matter
    Pages 275-286

About this book


This book has been written in response to the many physicians and scien­ tists working on the development of biological approaches to providing therapies for many orthopaedic disorders as well as to improving the healing of many tissues of the musculoskeletal system. The first goal of this book is to make the language compatible between the bench scientist and the clinician working in orthopaedic and sports medicine in order to cover specific areas of the orthopaedic discipline where the treatment can be improved and/or changed by the advancements in molecular medicine. Advancements in molecular biology, which encompass the study of the genetic basis of disease, have produced new diagnostic methods and drug therapies for genetic diseases and acquired disorders. The growth in the understanding of human genetics has also led to the initiation of many human gene therapy experiments. Although many approved therapeutic clinical trials using this new technology have been performed in the last ten years, the first clinical trial using this technology in the area of orthopaedics was performed at the University of Pittsburgh.


Osteogenesis imperfecta biology cartilage cell cells gene therapy genes medicine orthopaedics sports injury sports medicine surgery tissue tissue engineering trauma

Editors and affiliations

  • Johnny Huard
    • 1
  • Freddie H. Fu
    • 2
  1. 1.Growth and Development Laboratory Department of Orthopaedic Surgery and Molecular Genetics and BiochemistryChilren’s Hospital of Pittsburgh and University of PittsburghPittsburghUSA
  2. 2.Department of Orthopaedic Surgery Musculoskeletal Research Center Center for Sports MedicineUniversity of PittsburghPittsburghUSA

Bibliographic information