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Hormonal Carcinogenesis III

Proceedings of the Third International Symposium

  • Jonathan J. Li
  • Sara Antonia Li
  • Janet R. Daling

Table of contents

  1. Front Matter
    Pages i-xliii
  2. Symposium Address

    1. Gerald C. Mueller
      Pages 1-22
  3. State of the Art Lectures

    1. Front Matter
      Pages 23-23
    2. Jack Gorski, Tae-Yon Chun, Douglas Wendell
      Pages 25-36
    3. Arthur B. Pardee, Heide L. Ford, Debajit K. Biswas, Katherine J. Martin, Ruth Sager
      Pages 37-43
    4. Janet R. Daling, Kathleen E. Malone, Elaine A. Ostrander, Peggy L. Porter
      Pages 44-58
  4. Epidemiology: Breast and Prostate Cancer

    1. Front Matter
      Pages 59-59
    2. Kathleen E. Malone, Janet R. Daling, Nicola M. Suter, Kara Cushing, Thora Jonnasdottir, Elaine A. Ostrander
      Pages 70-86
    3. Janet L. Stanford
      Pages 87-96
  5. Molecular Genetics of Hormonal Cancers

    1. Front Matter
      Pages 97-97
    2. Frederic M. Waldman
      Pages 99-102
    3. C. Marcelo Aldaz, Andrzej Bednarek, April Charpentier, Michael MacLeod, Kathleen Hawkins, Kendra Laflin
      Pages 113-123
    4. Yvonne P. Dragan, Emile Nuwaysir, Linda Sargent, Dong-Hui Li, V. Craig Jordan, Henry C. Pitot
      Pages 124-135
  6. Estrogen Receptor Interactions

    1. Front Matter
      Pages 137-137
    2. Elwood V. Jensen
      Pages 139-143
    3. Jonathan J. Li, S. John Weroha, Marilyn Cansler, Sara Antonia Li
      Pages 149-157
  7. Estrogen/Progesterone-Breast Cancer

    1. Front Matter
      Pages 159-159
    2. Satyabrata Nandi, Raphael C. Guzman, Jason Yang, Lakshmanaswamy Rajkumar, Gudmundur Thordarson
      Pages 161-165
    3. Sara Antonia Li, Joshua DeZhong Liao, Jonathan J. Li
      Pages 178-188
    4. Kristen L. Murphey, Jeffrey M. Rosen
      Pages 189-197
  8. Cell Cycle, Cell Proliferation

    1. Front Matter
      Pages 199-199
    2. Richard P. DiAugustine, Diane M. Klotz, R. Gregg Richards
      Pages 201-205
    3. Valeria Belsito Petrizzi, Luigi Cicatiello, Lucia Altucci, Raffaele Addeo, Raphaelle Borgo, Massimo Cancemi et al.
      Pages 206-219
    4. Owen W. J. Prall, Eileen M. Rogan, Elizabeth A. Musgrove, Colin K. W. Watts, Robert L. Sutherland
      Pages 220-227
  9. Oncogenes/Tumor Suppressor Genes

    1. Front Matter
      Pages 229-229
    2. R. P. C. Shiu, D. Dubik, M. Venditti, J. Sparling, B. Iwasiow, P. H. Watson
      Pages 231-237
    3. Salman M. Hyder, Holly L. Boettger-Tong, Sari Mäkelä, George M. Stancel
      Pages 238-249
    4. Thomas C. Spelsberg, Malayannan Subramaniam, Katrina M. Waters, Theresa E. Hefferan, David J. Rickard, Gregory G. Reinholz
      Pages 250-260
  10. Aromatase: Implications for Breast Cancer

    1. Front Matter
      Pages 261-261
    2. Gregory A. Reed
      Pages 263-266
    3. Shiuan Chen, Dujin Zhou, Yeh-Chih Kao, Chun Yang, Baiba Grube
      Pages 267-276
    4. A. Singh, A. Purohit, M. W. Ghilchik, M. J. Reed
      Pages 277-284
    5. Robert W. Brueggemeier, Anne L. Quinn, Yasuro Sugimoto, Young C. Lin, Michelle L. Parrett, Farahnaz S. Joarder et al.
      Pages 285-298
  11. Organ Site: Prostate/Ovary

    1. Front Matter
      Pages 299-299
    2. Shutsung Liao, John M. Kokontis, Richard A. Hiipakka
      Pages 301-306
    3. Gerald R. Cunha, Simon W. Hayward, Thea Tlsty, Gary D. Grossfeld
      Pages 320-332
    4. Grant Buchanan, Wayne D. Tilley
      Pages 333-341
  12. Osteoporosis and Estrogen

    1. Front Matter
      Pages 343-343
    2. James H. Pickar
      Pages 345-347
    3. Michael Kleerekoper
      Pages 357-362
  13. Cardiovascular Disease and Estrogen/Progestins

  14. Viewpoint

    1. Front Matter
      Pages 385-385

About these proceedings

Introduction

Since our previous symposium in 1995, the pace of research in hormones and cancer has accelerated. Progress in our understanding of hormonal carcinogenic processes has been a direct result of the advances made in cell biology, endocrinology, and carcinogenesis at the molecular level. The newer fields of molecular genetics and cytogenetics already have and are expected to continue to playa major role in furthering our understanding of the cellular and molecular events in hormonal carcinogenesis. It has become increasingly clear that the risk of naturally occurring sex hormones in carcinogenic processes, both in human and in animal models, requires only minute quantities of hormones, at both the serum and tissue levels. Moreover, hormone target tissues for neoplastic transformation, perhaps with the exception of the liver, generally have relatively modest ability to metabolize sex hormones, such as the breast and prostate. Table 1 summarizes the serum, and in most cases, the tissue levels of sex hormones, both endogenously and exogenously ingested, which are associated with increased risk for endocrine-associated cancers such as breast, endometrium, and prostate, as well as the hormone levels of four experimental models that have been shown to elicit high tumor incidences. In contrast to the human, in which the hormone levels are cyclic, however, the latter require continuous hormone exposure at these relatively low levels.

Keywords

Hormonal Carcinogenesis carcinogenesis cell genetics hormones molecular genetics ovarian cancer prevention prostate cancer tumor

Editors and affiliations

  • Jonathan J. Li
    • 1
  • Sara Antonia Li
    • 1
  • Janet R. Daling
    • 2
  1. 1.Division of Etiology & Prevention of Hormonal Cancers Kansas Cancer IntituteUniversity of Kansas Medical CenterKansas CityUSA
  2. 2.Division of Public Health Sciences Fred Hutchinson Cancer Research CenterUniversity of WashingtonSeattleUSA

Bibliographic information