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Pharmacology of Endogenous Neurotoxins

A Handbook

  • Andreas Moser

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Neurotoxins

    1. Front Matter
      Pages 1-1
    2. Toshimitsu Niwa, Mitsuharu Kajita, Toshiharu Nagatsu
      Pages 3-23
    3. Makoto Naoi, Wakako Maruyama, Philippe Dostert
      Pages 41-61
    4. Michael A. Collins, Edward J. Neafsey
      Pages 129-149
    5. Gerhard Bringmann, Doris Feineis, Christoph Grote, Ralf God, Hans-Willi Clement, Karl-Heinz Sontag et al.
      Pages 151-169
  3. Metabolism

    1. Front Matter
      Pages 189-189
    2. Joachim Scholz, Andreas Moser
      Pages 221-236
    3. Clemens Neusch, Andreas Moser
      Pages 237-252
    4. Matthias F. Melzig, Ingo Putscher, Hanka Haber, Matthias Rottmann, Josef Zipper
      Pages 253-266
  4. Back Matter
    Pages 267-273

About this book

Introduction

It is a great pleasure to write the foreword to this important volume for several reasons. First: As far as we know, already primitive societies had to cope with environmental toxins of many kinds and set up regulations to limit their effects on food and drug use. Modem science, synthesizing tens of millions of new compounds has incredibly magnified this challenge. Today, xenobiotic metabolism has become a crucial task for humans and many other species alike. Second: When reading this book, one is impressed by the extraordinary speed at which neurotoxicology has advanced. Obviously, processing (and endogenous formation) oftox­ ins has become an extremely relevant topic. When I had the chance, almost three decades ago, to work in chemical pharmacology with Bernard B. Brodie at NIH, the drug metabo­ lizing system of the liver had just been recognized and characterized. We had just started to work on the biogenic amines, newly discovered cyclic nucleotides in rat brain, human cere­ brospinal fluid, and on the effects of toxic drugs like amphetamines. Today, biochemical neuropharmacology is a mature field of neuroscience.

Keywords

amphetamine brain drug metabolism neuropharmacology neuroscience neurotoxicology pharmacology research toxicology

Editors and affiliations

  • Andreas Moser
    • 1
  1. 1.Department of NeurologyMedical University of LübeckLübeckGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4612-2000-8
  • Copyright Information Springer Science+Business Media New York 1998
  • Publisher Name Birkhäuser, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4612-7375-2
  • Online ISBN 978-1-4612-2000-8
  • Buy this book on publisher's site