Growth Factors and Wound Healing

Basic Science and Potential Clinical Applications

  • Thomas R. Ziegler
  • Glenn F. Pierce
  • David N. Herndon

Part of the Serono Symposia USA Norwell, Massachusetts book series (SERONOSYMP)

Table of contents

  1. Front Matter
    Pages i-xviii
  2. General Concepts

    1. Front Matter
      Pages 1-1
    2. I. Kelman Cohen
      Pages 3-7
    3. Stephanie Rohovsky, Patricia A. D’Amore
      Pages 8-26
    4. John F. Hansbrough, Hans Oliver Rennekampff
      Pages 37-55
    5. Arvind Y. Krishna, Lawrence S. Phillips
      Pages 56-76
  3. Role of Nutrients in Wound Healing Responses

    1. Front Matter
      Pages 77-77
    2. Michael R. Schäffer, Adrian Barbul
      Pages 79-91
    3. Anders E. Ulland, Michael D. Caldwell
      Pages 92-103
    4. Thomas R. Ziegler, Alan B. Puckett, Daniel P. Griffith, John L. Galloway
      Pages 104-147
  4. Endogenous Growth Factors and Wound Healing

    1. Front Matter
      Pages 149-149
    2. David M. Ornitz, Gabriel Waksman
      Pages 151-174
    3. Wes J. Arlein, Michael D. Caldwell
      Pages 186-205
    4. Roy W. Tarnuzzer, Shawn P. Macauley, Bruce A. Mast, Jane S. Gibson, Michael C. Stacey, Naomi Trengrove et al.
      Pages 206-228
  5. Clinical Application of Growth Hormone and IGF-I Therapy

    1. Front Matter
      Pages 229-229
    2. David N. Herndon, Edgar J. Pierre, J. Keith Rose, Karina N. Stokes, Robert E. Barrow
      Pages 231-244
    3. Rafael Vara-Thorbeck, Estrella Ruiz-Requena, José Antonio Guerrero
      Pages 245-259

About this book

Introduction

The biology of wound healing and tissue repair are increasingly being defined. At the same time, the availability of recombinant peptide growth factors for clinical investigation has prompted numerous trials of growth factor administration as adjunctive therapy to enhance the rate and quality of acute and chronic wound repair. New basic science information on growth factor function and regulation obtained in the research laboratory is actively being applied in animal studies and in clinical research settings. In addition to studies of surface wounds, an increasing number of investiga­ tions on growth factor administration have focused on healing and repair in nondermal tissues such as the intestinal tract and other organs. While the amount of new information on the molecular biology of growth factor expression, signaling, and function has been exponential in recent years, results of many clinical trials on growth factor administration in wound healing have been disappointing. This may be due, in part, to the heterogeneity of clinical wounds and the patients who harbor them, less than adequate standardization of care in experimental and control groups, issues related to drug dosing, and inadequate control for important issues relevant to healing such as nutrient intake and underlying nutritional status.

Keywords

growth growth factor growth hormone hormone hormone therapy insulin-like

Editors and affiliations

  • Thomas R. Ziegler
    • 1
  • Glenn F. Pierce
    • 2
  • David N. Herndon
    • 3
  1. 1.Department of MedicineEmory University School of MedicineAtlantaUSA
  2. 2.Department of Preclinical DevelopmentPRIZM PharmaceuticalsSan DiegoUSA
  3. 3.Shriners Burns InstituteThe University of Texas Medical BranchGalvestonUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4612-1876-0
  • Copyright Information Springer-Verlag, New York, Inc. 1997
  • Publisher Name Springer, New York, NY
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4612-7321-9
  • Online ISBN 978-1-4612-1876-0
  • About this book