Multiple Organ Failure

Pathophysiology, Prevention, and Therapy

  • Arthur E. Baue
  • Eugen Faist
  • Donald E. Fry

Table of contents

  1. Front Matter
    Pages i-xxii
  2. Development of SIRS, MODS, and MOF

  3. Mechanisms of SIRS and Organ Failure

  4. Mediators and Effectors

    1. Front Matter
      Pages 143-143
    2. Lyle L. Moldawer, Rebecca M. Minter, John E. Rectenwald III
      Pages 145-154
    3. Aruna Nathan, Mervyn Singer
      Pages 167-175
    4. A. Neil Salyapongse, Timothy R. Billiar
      Pages 176-187
    5. Donald E. Fry
      Pages 188-195
    6. Geoffrey T. Manley, Mary J. Vassar, James W. Holcroft
      Pages 196-203
    7. M. Poeze, W. A. Buurman, G. Ramsay, J. W. M. Greve
      Pages 204-213
    8. Katrin Jurianz, Michael Kirschfink
      Pages 214-223
    9. Milind S. Shrotri, James C. Peyton, William G. Cheadle
      Pages 224-240
  5. Prevention and General Therapy

    1. Front Matter
      Pages 241-241
    2. Steffen Ruchholtz, Christian Waydhas, Dieter Nast-Kolb
      Pages 243-253
    3. Orlando C. Kirton, Joseph M. Civetta
      Pages 254-263
    4. Eduardo Bumaschny, Alejandro Rodríguez
      Pages 291-302
    5. Gina Quaid, Joseph S. Solomkin
      Pages 309-321
    6. Art Sanford, David N. Herndon
      Pages 322-329
  6. Specific Remote Organ Failures

    1. Front Matter
      Pages 331-331
    2. Jean-Louis Vincent
      Pages 333-339
    3. A. B. J. Groeneveld, L. G. Thijs
      Pages 340-352
    4. R. Phillip Dellinger
      Pages 353-364
    5. Timothy A. Pritts, David R. Fischer, Per-Olof Hasselgren
      Pages 378-388
    6. Eugen Faist, M. W. Wichmann
      Pages 389-397
    7. Jamie S. Ullman, Anthony H. Sin
      Pages 398-410
    8. Rodney M. Durham, Kelly Dreste
      Pages 411-419
    9. J. Heinrich Joist
      Pages 438-446
    10. Stig Bengmark
      Pages 447-458

About this book


Inflammation in itself is not to be considered as a disease . . . and in disease, where it can alter the diseased mode of action, it likewise leads to a cure; but where it cannot accomplish that solitary purpose . . . it does mischief - John Hunter, A Treatise on the Blood, ITfIlammation, and Gunshot Woundr (London, 1794)1 As we reached the millennium, we recognized the gap between our scientific knowledge of biologic processes and our more limited clinical capabilities in the care of patients. Our science is strong. Molecular biology is powerful, but our therapy to help patients is weaker and more limited. For this reason, this book focuses on the problems of multiple organ failure (MOF), multiple organ dysfunction syndrome (MODS), and systemic inflammatory response syndrome is, patients who have severe injuries; require major, (SIRS) in high-risk patients, that overwhelming operations; or have serious illnesses requiring intensive care; patients who have diseases elsewhere, in other organs or systems, that limit their capabilities to survive a new insult; and patients who are elderly or at high risk for sepsis or other complications. These are the patients who need our help. They need the advances in science, in molecular biology, immunology, pathophysiology, biochemistry, genetics, high technology, and other areas of maximum support at the bedside. These advances could potentially have the greatest impact on improving patient care.


Sepsis Surgery Trauma care central nervous system epidemiology fetus inflammation intensive care multiple organ failure pathophysiology physiology polytrauma prevention shock

Editors and affiliations

  • Arthur E. Baue
    • 1
  • Eugen Faist
    • 2
  • Donald E. Fry
    • 3
  1. 1.Department of SurgerySt. Louis University HospitalSt. LouisUSA
  2. 2.Department of Surgery, Klinikum GrosshadernUniversity of MunichMunichGermany
  3. 3.Department of Surgery, School of MedicineUniversity of New MexicoNew MexicoUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media New York 2000
  • Publisher Name Springer, New York, NY
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4612-7049-2
  • Online ISBN 978-1-4612-1222-5
  • Buy this book on publisher's site