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Drug Discovery

A Casebook and Analysis

  • Robert A. Maxwell
  • Shohreh B. Eckhardt

Table of contents

  1. Front Matter
    Pages i-xxv
  2. Cardiovascular and Renal Group (Including Renal Transplantation)

    1. Front Matter
      Pages 1-1
    2. Robert A. Maxwell, Shohreh B. Eckhardt
      Pages 3-18
    3. Robert A. Maxwell, Shohreh B. Eckhardt
      Pages 19-34
    4. Robert A. Maxwell, Shohreh B. Eckhardt
      Pages 35-51
    5. Robert A. Maxwell, Shohreh B. Eckhardt
      Pages 53-65
    6. Robert A. Maxwell, Shohreh B. Eckhardt
      Pages 67-77
    7. Robert A. Maxwell, Shohreh B. Eckhardt
      Pages 79-94
    8. Robert A. Maxwell, Shohreh B. Eckhardt
      Pages 95-108
  3. Psychiatry Group

    1. Front Matter
      Pages 109-109
    2. Robert A. Maxwell, Shohreh B. Eckhardt
      Pages 111-122
    3. Robert A. Maxwell, Shohreh B. Eckhardt
      Pages 123-132
    4. Robert A. Maxwell, Shohreh B. Eckhardt
      Pages 133-141
    5. Robert A. Maxwell, Shohreh B. Eckhardt
      Pages 143-154
    6. Robert A. Maxwell, Shohreh B. Eckhardt
      Pages 155-164
    7. Robert A. Maxwell, Shohreh B. Eckhardt
      Pages 165-175
  4. Neurology Group

    1. Front Matter
      Pages 177-177
    2. Robert A. Maxwell, Shohreh B. Eckhardt
      Pages 179-191
    3. Robert A. Maxwell, Shohreh B. Eckhardt
      Pages 193-206
  5. Rheumatology Group

    1. Front Matter
      Pages 207-207
    2. Robert A. Maxwell, Shohreh B. Eckhardt
      Pages 209-219
    3. Robert A. Maxwell, Shohreh B. Eckhardt
      Pages 221-233
    4. Robert A. Maxwell, Shohreh B. Eckhardt
      Pages 235-247
    5. Robert A. Maxwell, Shohreh B. Eckhardt
      Pages 249-263
    6. Robert A. Maxwell, Shohreh B. Eckhardt
      Pages 265-280
  6. Anesthesiology Group

    1. Front Matter
      Pages 281-281
    2. Robert A. Maxwell, Shohreh B. Eckhardt
      Pages 283-296
    3. Robert A. Maxwell, Shohreh B. Eckhardt
      Pages 297-305
    4. Robert A. Maxwell, Shohreh B. Eckhardt
      Pages 307-318
    5. Robert A. Maxwell, Shohreh B. Eckhardt
      Pages 319-330
  7. Pulmonary Group

    1. Front Matter
      Pages 331-331
    2. Robert A. Maxwell, Shohreh B. Eckhardt
      Pages 333-348
    3. Robert A. Maxwell, Shohreh B. Eckhardt
      Pages 349-362
  8. Gastrointestinal Group

    1. Front Matter
      Pages 363-363
    2. Robert A. Maxwell, Shohreh B. Eckhardt
      Pages 365-376
    3. Robert A. Maxwell, Shohreh B. Eckhardt
      Pages 377-388
  9. Analysis and Interpretation

    1. Front Matter
      Pages 389-389
    2. Robert A. Maxwell, Shohreh B. Eckhardt
      Pages 391-398
    3. Robert A. Maxwell, Shohreh B. Eckhardt
      Pages 399-416
  10. Back Matter
    Pages 417-438

About this book

Introduction

This treatise had its origins in the authors' strong opinion that the discovery of new drugs, especially of innovative therapeutic agents, really does not happen as a spontaneous sequel to investiga­ tive research, no matter how penetrating such research may be. Rather, it seemed to us that the discovery of innovative therapeutic agents was a very active process, existing in and of itself, and demanding full attention-it was not simply a passive, dependent by-process of investigative research. And yet, many researchers­ some close confreres of the authors, others more distant-believed otherwise. We felt that their view reflected unrealistic thinking and that reality probably lay closer to what Beyer" maintained: We are taught to believe that if we can understand a disease it should be easy enough to figure out, say, the molecular configuration of a definitive receptor mechanism somewhere along the line and to design a specific drug . . . . And so we start out to understand the disease but never get around to doing much about therapy. The authors very soon realized that there was essentially no quantitive information available on just where and how innovative therapeutic agents were discovered. There were only anecdotal accounts, and these were able to be selected and presented in ways that could be used to defend any point of view.

Keywords

calcium clinical research drug drug discovery research transplantation

Authors and affiliations

  • Robert A. Maxwell
    • 1
  • Shohreh B. Eckhardt
    • 2
  1. 1.The Wellcome Research LaboratoriesResearch Triangle ParkUSA
  2. 2.University of Vermont College of MedicineBurlingtonUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4612-0469-5
  • Copyright Information Springer Science+Business Media New York 1990
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4612-6775-1
  • Online ISBN 978-1-4612-0469-5
  • Buy this book on publisher's site