Molecular Neurovirology

Pathogenesis of Viral CNS Infections

  • Raymond P. Roos

Table of contents

  1. Front Matter
    Pages i-xx
  2. DNA Viruses

    1. Front Matter
      Pages 1-1
    2. Bernard Roizman, Leonard J. Kaplan
      Pages 3-23
  3. RNA Viruses with DNA Step in Replication

  4. RNA Viruses with Positive-Sense Genome and No DNA Step in Replication

    1. Front Matter
      Pages 249-249
    2. Akio Nomoto, Satoshi Koike
      Pages 251-281
    3. Michael M. C. Lai, Stephen A. Stohlman
      Pages 319-348
    4. Diane E. Griffin, Pamela C. Tucker, Steven L. Novick
      Pages 349-375
    5. Christopher H. Contag, John T. Harty, Peter G. W. Plagemann
      Pages 377-415
  5. RNA Viruses with Negative-Sense Genome and No DNA Step in Replication

    1. Front Matter
      Pages 417-417
    2. Sibylle Schneider-Schaulies, Volker ter Meulen
      Pages 419-448
    3. Francisco Gonzalez-Scarano, Michael Endres, David R. Jacoby, Christian Griot, Neal Nathanson
      Pages 449-469
  6. Unconventional Agents

    1. Front Matter
      Pages 471-471
    2. D. Carleton Gajdusek
      Pages 503-523
  7. A Challenge to Neurovirology: Human Immunodeficiency Virus and AIDS

    1. Front Matter
      Pages 525-525
    2. David J. Volsky, Muhammad Shahabuddin, Yaffa Mizrachi
      Pages 527-589
  8. Back Matter
    Pages 591-597

About this book


Neurovirology, the study of viral infection of the ner­ vous system, has evolved at the interface of three of the most rapidly unfolding fields of investigation-neurobiology, vi­ rology, and immunology. In all three, increasing knowledge about the molecular structure of surface receptors, how in­ tracellular messages are transmitted, and how diversity is regulated genetically is provided, along with the techniques of molecular biology. This promises to give us knowledge not only about the process of infection and the complex host and viral determinants of neuroinvasiveness and neurovirulence, but eventually it will provide the background from which to engineer vaccines and to devise novel therapeutic agents. Animal virology and molecular biology developed quite independently from different origins. Animal virology was originally the province of the pathologists, and by clinical observation and histological preparations, they tried to ex­ plain the incubation period, the pathways of virus spread, and the mechanisms of disease. Molecular virology grew out of biochemistry, particularly through studies of bacterio­ phage, with emphasis on the physical and chemical structure of viruses and the sequences of biochemical events during the replicative cycle in cells.


AIDS HIV Nervous System RNA central nervous system hepatitis immunodeficiency immunology infection information molecular biology neurology pathogenesis virology virus

Editors and affiliations

  • Raymond P. Roos
    • 1
  1. 1.University of Chicago Medical CenterChicagoUSA

Bibliographic information