• Dipak K. Dube

Part of the Cardiovascular Molecular Morphogenesis book series (CARDMM)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Assembly of Myofibrillar Proteins in Striated Muscle

    1. Front Matter
      Pages 1-1
    2. Joseph W. Sanger, Jean M. Sanger
      Pages 3-20
    3. Yutaka Shimada, Tin Moe Nwe, Fukuko Hasebe-Kishi, Homare Suzuki
      Pages 21-39
    4. Catherine McLellan, Carol C. Gregorio
      Pages 59-69
  3. Maintenance and Manipulation of Myofibrillar Organization

    1. Front Matter
      Pages 71-71
    2. Daniel E. Michele, Joseph M. Metzger
      Pages 73-85
    3. Robert W. Zajdel, Matthew D. McLean, Christopher R. Denz, Syamalima Dube, Larry F. Lemanski, Dipak K. Dube
      Pages 87-100
  4. Regulation of Expression of Myofibrillar Proteins

    1. Front Matter
      Pages 101-101
    2. Robert J. Schwartz, Jorge Sepulveda, Narasimhaswamy S. Belaguli
      Pages 103-127
    3. Paul J. R. Barton, Kimberley A. Dellow, Pankaj K. Bhavsar, Martin E. Cullen, Antony J. Mullen, Nigel J. Brand
      Pages 129-141
    4. M. A. Q. Siddiqui, Michael Wagner, Eduardo Mascareno, Saiyid Shafiq
      Pages 143-152
    5. Robert E. Welikson, Takashi Mikawa
      Pages 153-177
  5. Heart Development and Myofibrillar Organization

    1. Front Matter
      Pages 179-179
    2. Leonard M. Eisenberg, Carol A. Eisenberg
      Pages 181-205
    3. Larry F. Lemanski, Xupei Huang, R. W. Zajdel, Sharon L. Lemanski, Chi Zhang, Fanyin Meng et al.
      Pages 207-222
  6. Cardiomyopathy and Myofibrillar Organization

    1. Front Matter
      Pages 223-223
    2. Rethinasamy Prabhakar, Kathy Pieples, Ganapathy Jagatheesan, Stephanie Burge, David F. Wieczorek
      Pages 225-235
    3. Jeffrey A. Towbin, Neil E. Bowles
      Pages 237-263
  7. Back Matter
    Pages 265-270

About this book


Myofibrillogenesis has been studied extensively over the last 100 years. Until recently, we have not had a comprehensive understanding of this fundamental process. The emergence of new technologies in molecular and cellular biology, combined with classical embryology, have started to unravel some of the complexities of myofibril assembly in striated muscles. In striated muscles, the contractile proteins are arranged in a highly ordered three dimensional lattice known as the sarcomere. The assembly of a myofibril involves the precise ordering of several proteins into a linear array of sarcomeres. Multiple isoforms in many of these proteins further complicate the process, making it difficult to define the precise role of each component. This volume has been compiled as a comprehensive reference on myofibrillogenesis. In addition, the book includes reviews on myofibrillar disarray under various pathological conditions, such as familial hypertrophic cardiomyopathy (FHC), and incorporates a section on the conduction system in the heart. Much of the information in this volume has not been described elsewhere. Presented in a manner to be of value to students and teachers alike, "Myofibrillogenesis" will be an invaluable reference source for all in the fields of muscle biology and heart development.


biology cell development embryology gene gene expression heart phenotype protein proteins regulation signal transduction system

Editors and affiliations

  • Dipak K. Dube
    • 1
  1. 1.Department of Medicine and Department of Cell and Developmental BiologySUNY Upstate Medical UniversitySyracuseUSA

Bibliographic information