Multiscale Modeling in Biomechanics and Mechanobiology

  • Suvranu De
  • Wonmuk Hwang
  • Ellen Kuhl

Table of contents

  1. Front Matter
    Pages i-viii
  2. Multiscale Modeling Around the Molecular Level

    1. Front Matter
      Pages 1-1
    2. Albert K. Dearden, Saroj K. Nayak
      Pages 3-12
    3. Stefan Klumpp, Corina Keller, Florian Berger, Reinhard Lipowsky
      Pages 27-61
  3. Multiscale Modeling Around the Cellular and Tissue Level

    1. Front Matter
      Pages 85-85
    2. Y.-N. Young, Lina C. Espinha, An M. Nguyen, Christopher R. Jacobs
      Pages 87-110
    3. Milos Kojic, Miljan Milosevic, Nikola Kojic, Velibor Isailovic, Dejan Petrovic, Nenad Filipovic et al.
      Pages 131-156
  4. Multiscale Modeling Around the Organ Level

    1. Front Matter
      Pages 157-157
    2. Shawn P. Reese, Jeffrey A. Weiss
      Pages 159-206
    3. Chung-Hao Lee, Rouzbeh Amini, Yusuke Sakamoto, Christopher A. Carruthers, Ankush Aggarwal, Robert C. Gorman et al.
      Pages 223-255
    4. Yusheng Feng, Sarah J. Boukhris, Rakesh Ranjan, Raul A. Valencia
      Pages 257-286

About this book


Presenting a state-of-the-art overview of theoretical and computational models that link characteristic biomechanical phenomena, this book provides guidelines and examples for creating multiscale models in representative systems and organisms. It develops the reader's understanding of and intuition for multiscale phenomena in biomechanics and mechanobiology, and introduces a mathematical framework and computational techniques paramount to creating predictive multiscale models.


Biomechanics involves the study of the interactions of physical forces with biological systems at all scales – including molecular, cellular, tissue and organ scales. The emerging field of mechanobiology focuses on the way that cells produce and respond to mechanical forces – bridging the science of mechanics with the disciplines of genetics and molecular biology. Linking disparate spatial and temporal scales using computational techniques is emerging as a key concept in investigating some of the complex problems underlying these disciplines.


Providing an invaluable field manual for graduate students and researchers of theoretical and computational modelling in biology, this book is also intended for readers interested in biomedical engineering, applied mechanics and mathematical biology.


Biomechanics and Mechanobiology Genetics and Molecular Biology computational techniques applied to molecular biology creating predictive multiscale models multiscale modeling and biomedical engineering multiscale modeling and mathematical biology multiscale modeling in biomechanics and mechanobiology multiscale phenomena in biomechanics and mechanobiology theoretical and computational models biomechanical phenomena theoretical and computational models in biomechanics theoretical and computational models in mechanobiology

Editors and affiliations

  • Suvranu De
    • 1
  • Wonmuk Hwang
    • 2
  • Ellen Kuhl
    • 3
  1. 1.Dept. of Mechanical, Aerospace & Nuclear EngineeringRensselaer Polytechnic InstituteTroyUSA
  2. 2.Dept. of Biomedical EngineeringTexas A&M UniversityCollege StationUSA
  3. 3.Dept.of Mechanical Engineering Bioengineering & Cardiothoracic SurgeryStanford UniversityStanfordUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag London 2015
  • Publisher Name Springer, London
  • eBook Packages Engineering
  • Print ISBN 978-1-4471-6598-9
  • Online ISBN 978-1-4471-6599-6
  • Buy this book on publisher's site