Trichloroethylene: Toxicity and Health Risks

  • Kathleen M. Gilbert
  • Sarah J. Blossom

Part of the Molecular and Integrative Toxicology book series (MOLECUL)

Table of contents

  1. Front Matter
    Pages i-x
  2. Richard E. Doherty
    Pages 1-14
  3. Michihiro Kamijima, Hailan Wang, Osamu Yamanoshita, Yuki Ito, Tamie Nakajima
    Pages 37-52
  4. M. Firoze Khan, Gangduo Wang
    Pages 53-71
  5. Samuel M. Goldman, Stephanie Whisnant Cash
    Pages 91-129
  6. Sarah J. Blossom
    Pages 131-151
  7. Ornella I. Selmin, Om Makwana, Raymond B. Runyan
    Pages 153-169
  8. Daniel Wartenberg, Kathleen M. Gilbert
    Pages 171-184
  9. Craig A. Cooney
    Pages 185-208
  10. Brad Reisfeld, Jaime H. Ivy
    Pages 209-237
  11. Back Matter
    Pages 239-245

About this book


A comprehensive overview of the effects of trichloroethylene toxicity caused by real-life exposure levels highlighting how exposure to trichloroethylene may contribute to the etiology of several idiopathic human diseases. Discussion will focus on different kinds of modeling and how they may be used to predict functional consequences and to dissect the contribution of different mechanistic pathways, including potential mechanisms of action for trichloroethylene toxicity in different organ systems. It will explore the role of epigenetic alterations in trichloroethylene toxicity, this provides important mechanistic information and may also provide the basis for intervention therapy. Chapters will also explain how the risks from trichloroethylene exposure may be greater in certain populations based on genetic predisposition, age of exposure and co-exposure to other chemicals With contributions from international experts in the field, Trichloroethylene: Toxicity and Health Risks is an essential resource for researchers and clinicians in toxicology, immunology, medicine and public health as well as industry and government regulatory scientists involved in safety and health protection and epidemiologists, highlighting the need for interdisciplinary cooperation in solving issues of environmental toxicity.


Endocrine Epigenetic Immunotoxicity Nephrotoxicity Neurotoxicity trichloroethylene

Editors and affiliations

  • Kathleen M. Gilbert
    • 1
  • Sarah J. Blossom
    • 2
  1. 1.Department of Microbiology and Immunology, Arkansas Children’s Hospital Research InstituteUniversity of Arkansas for Medical SciencesLittle RockUSA
  2. 2.Department of Pediatrics, Arkansas Children’s Hospital Research InstituteUniversity of Arkansas for Medical SciencesLittle RockUSA

Bibliographic information