Patent Foramen Ovale

  • Zahid Amin
  • Jonathan M. Tobis
  • Horst Sievert
  • John D. Carroll

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Background and Anatomy

    1. Front Matter
      Pages 1-1
    2. John F. Rhodes Jr., Amanda Green
      Pages 3-5
    3. Hussam Suradi, Zahid Amin
      Pages 15-24
    4. Robert J. Sommer, Barbara T. Spencer
      Pages 25-30
  3. Methods and Techniques for Detection and Characterization of PFO

    1. Front Matter
      Pages 31-31
    2. Eustaquio Maria Onorato, Francesco Casilli, Gian Paolo Anzola
      Pages 33-47
    3. Noa Holoshitz, Ziyad M. Hijazi
      Pages 49-53
    4. M. Khalid Mojadidi, Rubine Gevorgyan, Jonathan M. Tobis
      Pages 55-65
    5. Daniel R. Turner, Thomas J. Forbes
      Pages 67-73
  4. PFO and Clinical Syndromes

    1. Front Matter
      Pages 75-75
    2. James Orford, Brian Whisenant
      Pages 77-79
    3. M. Khalid Mojadidi, Nimit Dave, Rubine Gevorgyan, Jonathan M. Tobis
      Pages 81-94
    4. John D. Carroll, Sharon Poisson, Michael S. Kim
      Pages 95-106
    5. Carla Canniffe, Kevin P. Walsh
      Pages 107-111
    6. Omar Ali, Ted Feldman
      Pages 113-117
    7. Tomas Konecny, Guy S. Reeder, Virend K. Somers
      Pages 119-122
    8. John D. Carroll
      Pages 123-127
    9. Robert J. Sommer, Barbara T. Spencer
      Pages 129-134
  5. Closure Methods

    1. Front Matter
      Pages 135-135
    2. Gary Cheung, Lars Søndergaard
      Pages 137-143
    3. Jennifer Franke, Sameer Gafoor, Horst Sievert
      Pages 157-162
    4. Khaled Mansoor, Zahid Amin
      Pages 163-169
  6. Statistical Methods, Trials and Tribulations

    1. Front Matter
      Pages 171-171
    2. M. Khalid Mojadidi, Rubine Gevorgyan, Jonathan M. Tobis
      Pages 173-179
    3. John F. Rhodes Jr., Scott E. Kasner
      Pages 181-184
    4. Ahmed A. Khattab, Bernhard Meier
      Pages 185-188
    5. Bray Patrick-Lake
      Pages 199-202
    6. M. Khalid Mojadidi, Rubine Gevorgyan, Jonathan M. Tobis
      Pages 203-209
  7. Difficulties/Obstacles in Starting PFO Closure Practice

    1. Front Matter
      Pages 223-223
    2. Christian Spies, Brittney Patterson-Lazzaro
      Pages 225-228
    3. Sherman G. Sorensen
      Pages 229-243

About this book


This book is the ultimate reference on patent foramen ovale (PFO), a defect in the septum of the heart estimated to be present in more than twenty percent of the adult population and a proven cause of systemic embolism. All chapters have been written by internationally recognized experts in the field and cover PFO genetics and anatomy in addition to the effect PFO can have on various different organs and its supposed involvement in several conditions and clinical syndromes such as migraine, diving incidence, platynea orthodeoxia, economy class syndrome, sleep apnea and persistent desaturations in mild right ventricular dysfunction.

 As PFO anatomy varies significantly between individuals, chapters have also been included on the diagnostic tools, methods and techniques for appropriate assessment, detection and characterization of PFO. Furthermore, the multitude of available closure devices and techniques for PFO closure are discussed together with current and ongoing trial data. The book concludes with guidance and instruction on establishing a successful PFO program.

 Patent Foramen Ovale will be an essential text for the whole adult and pediatric interventional community, general cardiologists, internists, primary care physicians, neurologists, and device companies in addition to medical students, graduate students and fellows in training.


Deep sea diving Gore trial Migraine PC trial PFO Patent Foramen Ovale Percutaneous Closure Platynea Orthodeoxia RESPECT Sleep Apnea Transplant

Editors and affiliations

  • Zahid Amin
    • 1
  • Jonathan M. Tobis
    • 2
  • Horst Sievert
    • 3
  • John D. Carroll
    • 4
  1. 1.Children's Hospital of GeorgiaAugustaUSA
  2. 2.UCLALos AngelesUSA
  3. 3.CardioVascular CenterFrankfurtGermany
  4. 4.University of Colorado Denver Anschutz Medical CampusAuroraUSA

Bibliographic information