Biological and Clinical Aspects

  • Michael G. Chapman
  • J. Gedis Grudzinskas
  • Tim Chard

Table of contents

  1. Front Matter
    Pages i-xii
  2. General

    1. Front Matter
      Pages 1-1
    2. J. P. Hearn, G. E. Webley, A. A. Gidley-Baird
      Pages 3-13
  3. Pituitary and Ovarian Hormones

    1. Front Matter
      Pages 15-15
  4. Placental Hormones and Proteins

  5. Endometrial/Decidual Proteins

    1. Front Matter
      Pages 93-93
    2. M.-L. Huhtala, M. Seppälä, M. Julkunen, R. Koistinen
      Pages 119-134
    3. A. E. Bolton, A. G. Pockley, E. A. Mowles, R. J. Stoker, O. M. R. Westwood, M. G. Chapman
      Pages 135-144
  6. Prostaglandins in Reproduction

    1. Front Matter
      Pages 145-145
    2. S. K. Smith, R. W. Kelly
      Pages 147-160
  7. Reproductive Immunology

    1. Front Matter
      Pages 161-161
    2. B. Teisner, D. Tornehave, J. Hau, J. G. Westergaard, H. K. Poulsen
      Pages 177-182
    3. W. R. Jones
      Pages 197-203
  8. Clinical Aspects

    1. Front Matter
      Pages 205-205
    2. A. F. Riddle, I. Stabile, V. Sharma, S. Campbell, B. A. Mason, J. G. Grudzinskas
      Pages 207-215
    3. I. Stabile, J. G. Westergaard, J. G. Grudzinskas
      Pages 229-238
    4. J. L. Yovich
      Pages 239-254
  9. Back Matter
    Pages 255-258

About this book


The advent of assisted conception procedures such as in-vitro fertili­ sation (IVF) has provided the impetus for exploration of the factors that lead to the establishment of pregnancy. This collection of papers from leading research workers brings together current concepts of the processes which may be of importance in implantation. The complex signals from the embryo to the ovary, endometrium and myometrium are now being revealed through studies in both primates and other mammalian species. This book addresses the interrelationship of pituitary and ovarian hormones in controlling ovulation and the preparation of the intrauterine environment for implantation. Once fertilisation has occurred and trophoblast has formed, the next vital step is the production of materials which signal the presence of the pregnancy to the rest of the body. Trophoblastic proteins and other early-pregnancy factors are prime candidates for this role. Recent studies have emphasised the importance of the intrauterine environment in implantation. Specific secretory products of the endometrium have great potential in this process. The prostaglandins also play an essential part. Immunological adjustments are now considered a condition for the successful establishment of pregnancy. The possible use of immuno­ therapy in the treatment of recurrent abortion has highlighted interest in this area. The use of immunological techniques for contraception are in their infancy but offer much hope for the future.


biochemistry contraception embryo endocrinology fertility hormones immunology infertility metabolism placenta pregnancy prostaglandins protein reproduction synthesis

Editors and affiliations

  • Michael G. Chapman
    • 1
  • J. Gedis Grudzinskas
    • 2
  • Tim Chard
    • 3
  1. 1.Department of Obstetrics and GynaecologyGuy’s HospitalLondonUK
  2. 2.Academic Unit of Obstetrics and GynaecologyThe London Hospital, WhitechapelLondonUK
  3. 3.Academic Unit of Reproductive PhysiologySt Bartholomew’s Hospital Medical CollegeLondonUK

Bibliographic information