Prostaglandins and the Uterus

  • James O. Drife
  • Andrew A. Calder

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Menstruation

    1. Front Matter
      Pages 1-1
    2. R. W. Kelly, L. Cheng, J. Thong, E. L. Yong, D. T. Baird
      Pages 3-15
    3. I. T. Cameron
      Pages 17-32
    4. C. M. P. Rees
      Pages 33-43
    5. I. S. Fraser
      Pages 67-87
  3. Early Pregnancy

    1. Front Matter
      Pages 89-89
    2. S. K. Smith
      Pages 91-99
    3. J. E. Norman
      Pages 101-118
    4. I. Z. MacKenzie
      Pages 119-133
    5. A. Rådestad
      Pages 135-146
  4. Parturition

    1. Front Matter
      Pages 147-147
    2. D. M. Olson, T. Zakar, Z. Smieja, E. A. MacLeod, S. L. Brown
      Pages 149-160
    3. P. W. N. Nathanielsz, M. B. O. M. Honnebier
      Pages 161-180
    4. P. Husslein
      Pages 181-190
    5. I. A. Greer
      Pages 191-209
  5. Preterm Labour

    1. Front Matter
      Pages 211-211
    2. A. López Bernal, S. P. Watson
      Pages 213-235
    3. M. G. Elder
      Pages 237-255
    4. J. J. Amy, H. Cammu
      Pages 257-276
  6. Back Matter
    Pages 297-301

About this book


The introduction of prostaglandins into clinical practice has been one of the most important advances in obstetrics and gynaecology in recent years. During the last decade obstetricians have become familiar with these drugs for inducing labour and for terminating second-trimester pregnancy. Within the last year their use has been extended, in association with antiprogestin, to first-trimester termi­ nation. Although the effectiveness of prostaglandins in these pharma­ cological roles is clear, their full potential has still to be explored, and much remains to be learned about their physiology. Prostaglandins playa central role in the initiation of labour. Further clarification of this role could lead to improvements in preventing or treating preterm labour, which still remains the most important cause of perinatal mortality in this country. Prostaglandins are also inti­ mately involved in the mechanism of menstruation. More detailed understanding of this role should lead to more effective treatments for menorrhagia and dysmenorrhoea. These substances also playa part in the mechanism of implantation, and further research in this area may lead to more effective therapy for infertility.


Uterus endocrinology infection pregnancy regulation

Editors and affiliations

  • James O. Drife
    • 1
  • Andrew A. Calder
    • 2
  1. 1.Department of Obstetrics and GynaecologyClarendon Wing, Leeds General InfirmaryBelmont GroveUK
  2. 2.Department of Obstetrics and GynaecologyThe University of Edinburgh, Centre for Reproductive BiologyEdinburghUK

Bibliographic information