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Diseases of the Human Carotid Body

  • Donald Heath
  • Paul Smith

Table of contents

  1. Front Matter
    Pages i-xii
  2. Donald Heath, Paul Smith
    Pages 1-6
  3. Donald Heath, Paul Smith
    Pages 7-13
  4. Donald Heath, Paul Smith
    Pages 15-24
  5. Donald Heath, Paul Smith
    Pages 31-41
  6. Donald Heath, Paul Smith
    Pages 43-48
  7. Donald Heath, Paul Smith
    Pages 49-61
  8. Donald Heath, Paul Smith
    Pages 63-72
  9. Donald Heath, Paul Smith
    Pages 73-79
  10. Donald Heath, Paul Smith
    Pages 81-89
  11. Donald Heath, Paul Smith
    Pages 91-100
  12. Donald Heath, Paul Smith
    Pages 101-105
  13. Donald Heath, Paul Smith
    Pages 107-118
  14. Donald Heath, Paul Smith
    Pages 119-126
  15. Donald Heath, Paul Smith
    Pages 127-131
  16. Donald Heath, Paul Smith
    Pages 133-141
  17. Donald Heath, Paul Smith
    Pages 143-151
  18. Donald Heath, Paul Smith
    Pages 153-160
  19. Donald Heath, Paul Smith
    Pages 161-178
  20. Donald Heath, Paul Smith
    Pages 179-189
  21. Donald Heath, Paul Smith
    Pages 191-197
  22. Back Matter
    Pages 199-205

About this book

Introduction

Ever since its discovery in 1742 the carotid body has remained an organ of mystery. Originally described as a ganglion, it was subsequently regarded as a gland, chromaffin paraganglion and non-chromaffin paraganglion. In 1928 it was shown to be a chemoreceptor with close associations with the function of baroreception in the adjacent carotid sinus and perhaps within its own substance. These discoveries led physiologists to embark on a series of elegant experimental studies on a number of animal species which have, however, so far failed to identify the transducer for detection of changes in tension of arterial blood gases or the mechanism of chemor­ eception. Pathologists on the other hand have largely ignored the carotid body, restricting their interest to its tumour, the chemodectoma. A remarkable disparity in knowledge of the organ has resulted, with most information being available on the physiology of chemoreceptor tissue in laboratory animals. In contrast, there has been sparse interest and awareness of the pathology in man of this nodule of tissue lying in the carotid bifurcation whose functional activity is suggested by the high blood flow it receives, and its rich content of biogenic amines and a wide variety of peptides. This book is an attempt to redress this unsatisfactory situation. During the last few years our understanding of the detailed histology and ultrastructure of the human carotid body has improved.

Keywords

Chemodectoma Chronic carotid glomitis Human carotid body Sudden infant death syndrome physiology

Authors and affiliations

  • Donald Heath
    • 1
  • Paul Smith
    • 2
  1. 1.Department of PathologyUniversity of Liverpool Royal Liverpool University HospitalLiverpoolUK
  2. 2.Department of PathologyLiverpoolUK

Bibliographic information