The Embryo

Normal and Abnormal Development and Growth

  • Michael G. Chapman
  • J. Gedis Grudzinskas
  • Tim Chard

Table of contents

  1. Front Matter
    Pages i-xi
  2. P. Braude, M. Johnson, S. Pickering, C. Vincent
    Pages 1-10
  3. J. L. Simpson
    Pages 11-34
  4. I. Stabile
    Pages 35-43
  5. J. L. Yovich
    Pages 45-62
  6. V. N. Bolton
    Pages 63-79
  7. R. J. Lilford, H. Irving, J. K. Gupta, P. O’Donovan, G. Linton
    Pages 91-100
  8. K. H. Nicolaides, R. J. M. Snijders, C. M. Gosden
    Pages 101-121
  9. E. A. Reece, J. C. Hobbins
    Pages 123-140
  10. J. D. West
    Pages 141-164
  11. B. Brambati, A. Lanzani, L. Tului
    Pages 181-194
  12. J. G. Grudzinskas, T. Chard
    Pages 195-207
  13. R. Koistinen, M. Julkunen, L. Riittinen, A. M. Suikkari, M. Seppälä
    Pages 227-239
  14. N. Wald, H. Cuckle
    Pages 251-257
  15. Back Matter
    Pages 259-263

About this book


A variety of new techniques that promise to revolutionize the clinical management of early pregnancy are fully detailed in this state-of-the-art book. Leading international researchers describe fast-moving topics such as embryo manipulation and the diagnosis of congenital abnormalities. The technology of assisted reproduction has made it possible to study living embryonic material for the first time, which has led to rapid advances in our understanding of the human embryo's early development. For example, study of the embryo in the test tube has pointed to early pregnancy loss as a possible cause of later infertility. Even more important, diagnostic tests using sophisticated techniques of molecular biology can be run on single cells before the embryo is replaced in the uterus. Another area of advance is the diagnosis of congenital abnormalities in the first and second trimesters of pregnancy. Great improvements have been made in the techniques of chorion villus biopsy and ultrasound imaging. A spectrum of simple biochemical tests performed on the mother's blood can greatly improve the detection of Down syndrome and other chromosome defects. Together with other developments in the fields of molecular biology and endocrinology, these new diagnostic techniques are the beginning of a new age in clinical human genetics and embryology.


Chromosom Embryologie Endokrinologie Erbkrankheit Uterus assisted reproduction development embryo endocrinology genetics growth infertility pregnancy reproduction ultrasound

Editors and affiliations

  • Michael G. Chapman
    • 1
  • J. Gedis Grudzinskas
    • 2
  • Tim Chard
    • 3
  1. 1.Department of Obstetrics and GynaecologyGuy’s HospitalLondonUK
  2. 2.Academic Unit of Obstetrics and GynaecologyThe London HospitalWhitechapel, LondonUK
  3. 3.Academic Unit of Reproductive PhysiologySt Bartholomew’s Hospital Medical CollegeLondonUK

Bibliographic information