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Platelet-Vessel Wall Interactions

  • R. Michael Pittilo
  • Samuel J. Machin

Part of the The Bloomsbury Series in Clinical Science book series (BLOOMSBURY)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Ian J. Mackie, Christopher R. Neal
    Pages 1-32
  3. R. Michael Pittilo
    Pages 33-59
  4. R. Michael Pittilo
    Pages 87-101
  5. Carol M. Blow
    Pages 103-119
  6. Guy H. Neild, Michael P. Gordge
    Pages 121-153
  7. Anne Yardumian, Samuel J. Machin
    Pages 167-191
  8. Back Matter
    Pages 193-198

About this book

Introduction

The publication of Platelet-Vessel Wall Interactions, the second monograph in the Bloomsbury Series in Clinical Science, is particu­ larly welcome as its appearance signifies the further development of the Series and its potential for the future. The theme of this monograph is the pathophysiology of atherosclerosis, a topic that symbolises the aim of the Series, namely to highlight the important interfaces between basic medical science and clinical practice. Our congratulations to the Editors and contributors. London, December 1987 lack Tinker Preface In the Western world, atherosclerosis causes more illness and death than any other disease. Despite its devastating effects, the pathogenesis of the disease remains a matter for hypothesis and con­ jecture. This monograph owes its conception to a programme of work directed towards understanding the basic pathophysiology of atherosclerosis. The circulatory system is lined by vascular endothelium which has a central role in maintaining the integrity of the vessel wall and prevent­ ing thrombosis. The natural equilibrium existing between normal en­ dothelium which supports blood flow, and platelets which serve to re­ pair damaged endothelium, is explored in the first two chapters. Atherosclerosis developing as a response to endothelial injury is one hypothesis which has stimulated widespread interest, and re­ search has largely been directed towards finding the injurious agent.

Keywords

atherosclerosis blood physiology platelet thrombosis

Editors and affiliations

  • R. Michael Pittilo
    • 1
    • 2
  • Samuel J. Machin
    • 3
  1. 1.Bland-Sutton Institute, Department of HistopathologyThe Middlesex HospitalLondonUK
  2. 2.Department of Analytical and Biological ChemistryKingston PolytechnicKingston-upon-Thames, SurreyUK
  3. 3.Department of Haematology, School of PathologyThe Middlesex HospitalLondonUK

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4471-1455-0
  • Copyright Information Springer-Verlag London 1988
  • Publisher Name Springer, London
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4471-1457-4
  • Online ISBN 978-1-4471-1455-0
  • Series Print ISSN 0939-2491
  • Buy this book on publisher's site