Insulin Resistance and Cancer

Epidemiology, Cellular and Molecular Mechanisms and Clinical Implications

  • I. George Fantus

Part of the Energy Balance and Cancer book series (EBAC, volume 1)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Sandra Pereira, Adria Giacca
    Pages 1-52
  3. Cullen M. Taniguchi, C. Ronald Kahn
    Pages 53-76
  4. Melinda L. Irwin
    Pages 101-110
  5. Lorraine Lipscombe
    Pages 111-140
  6. Ruslan Novosyadlyy, Archana Vijayakumar, Yvonne Fierz, Derek LeRoith
    Pages 141-157
  7. Yael Babichev, Sarah Khalid, I. George Fantus
    Pages 159-180
  8. Luc Furic, Mark Livingstone, Ivan Topisirovic, Nahum Sonenberg
    Pages 181-192
  9. Bin Zheng, Lewis C. Cantley
    Pages 193-211
  10. Antonino Belfiore, Ira D. Goldfine, Roberta Malaguarnera
    Pages 243-268
  11. Back Matter
    Pages 293-298

About this book

Introduction

This book reviews the epidemiological associations between insulin resistance and cancer. This is followed by reviews of animal models which support this relationship and provide insight into potential mechanisms. Several chapters then provide detailed examination of the cellular and molecular changes characterizing the insulin resistant state, such as hyperinsulinemia, abnormal metabolism and hormone signaling, and how these interact with various tumor characteristics. For example some tumors present increased quantities of the fetal form of the insulin receptor, unique regulation of oxidative (Krebs’ cycle) metabolism (Warburg effect), as well as mutations in various relevant signaling pathways. Finally, the clinical implications of these data are integrated with considerations of insulin “sensitization” and potential metabolic interventions to prevent and treat cancer. It should be noted that while a number of cancers are associated with obesity the authors here have focused primarily on breast cancer as a key and significant model.

Keywords

Hyperinsulinemia IGF Receptors breast cancer metabolic syndrome obesity

Editors and affiliations

  • I. George Fantus
    • 1
  1. 1.Mount Sinai Hospital, Dept. MedicineUniversity of TorontoTorontoCanada

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4419-9911-5
  • Copyright Information Springer Science+Business Media, LLC 2011
  • Publisher Name Springer, New York, NY
  • eBook Packages Medicine
  • Print ISBN 978-1-4419-9910-8
  • Online ISBN 978-1-4419-9911-5
  • About this book