Controlled Pulmonary Drug Delivery

  • Hugh D.C. Smyth
  • Anthony J. Hickey

Part of the Advances in Delivery Science and Technology book series (ADST)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Kevin P. O’Donnell, Hugh D. C. Smyth
    Pages 1-19
  3. Bo Olsson, Eva Bondesson, Lars Borgström, Staffan Edsbäcker, Stefan Eirefelt, Katarina Ekelund et al.
    Pages 21-50
  4. Ibrahim M. El-Sherbiny, Diana G. Villanueva, Dea Herrera, Hugh D. C. Smyth
    Pages 101-126
  5. Jennifer Fiegel, Timothy Brenza, Rania Hamed
    Pages 143-163
  6. Sandro R. P. da Rocha, Balaji Bharatwaj, Sowmya Saiprasad
    Pages 165-201
  7. Timothy M. Crowder, Martin J. Donovan
    Pages 203-222
  8. Aileen Gibbons, Hugh D. C. Smyth
    Pages 223-236
  9. Poonam Sheth, Paul B. Myrdal
    Pages 237-263
  10. Poonam Sheth, Paul B. Myrdal
    Pages 265-282
  11. Nashwa El-Gendy, Mark M. Bailey, Cory Berkland
    Pages 283-312
  12. Janani Swaminathan, Carsten Ehrhardt
    Pages 313-334
  13. Alan B. Watts, Robert O. Williams III
    Pages 335-366
  14. Simon Heuking, Gerrit Borchard
    Pages 367-381
  15. Yoen-Ju Son, Jolyon P. Mitchell, Jason T. McConville
    Pages 383-415
  16. Stephen T. Buckley, Kwang-Jin Kim, Carsten Ehrhardt
    Pages 417-442
  17. Philip J. Kuehl
    Pages 475-487
  18. Stephen T. Horhota, Stefan Leiner
    Pages 529-541
  19. Back Matter
    Pages 543-557

About this book


This distinctive text provides a toolbox for pharmaceutical scientists and those involved in product development utilizing pulmonary drug delivery systems. Uniquely focusing on aspects of control, both temporal and spatial, the text collects a broad range of interlinked chapters that provide both theoretical and practical insight.


Controlled Pulmonary Drug Delivery begins by examination of the foundations for pulmonary drug delivery: the macro and microstructure of the airways, lung clearance, airway absorption and transport, aerosol physics, and a historical overview of the field. Unlike other texts, these chapters are written specifically with drug delivery in mind. The science and technology of inhaler devices, technologies, materials, and particles systems are covered. Testing methods and techniques are discussed before regulatory perspectives and performance specifications conclude the text. The twenty two novel chapters in this volume each provide a theoretical and practical set of tools that comprise a comprehensive toolbox.


This volume will be of interest to scientists and engineers developing pulmonary drug delivery systems. The unique themes of controlled release science and technology that run through the book ensure that experienced and newcomers will greatly benefit from this book. As the importance for control over therapeutic performance is better recognized and demanded, this text will be essential for those delivering bioactives to the lung.

Dr. Hugh Smyth is Assistant Professor of Pharmaceutics at the University of Texas, Austin. He is a recipient of the Young Investigator in Pharmaceutics and Pharmaceutical Technology Award of the American Association of Pharmaceutical Scientists and has edited a volume on pulmonary drug delivery. Drs. Hickey and Smyth share a research interest in the delivery of drugs to the lungs for the treatment and prevention of a number of diseases.

Dr. Anthony Hickey is Professor of Molecular Pharmaceutics and Biomedical Engineering at the University of North Carolina at Chapel Hill. He is a fellow of the Institute of Biology, American Association of Pharmaceutical Scientists and the American Association for the Advancement of Science. He has published several edited and authored volumes in the fields of pharmaceutical aerosols, process engineering and particulate science.


Controlled Delivery Hickey Pulmonary Release Science Smyth Technology

Editors and affiliations

  • Hugh D.C. Smyth
    • 1
  • Anthony J. Hickey
    • 2
  1. 1., Pharmaceutics Division - PHR 4.214University of TexasAustinUSA
  2. 2.Eshelman School of Pharmacy, Division of Molecular PharmaceuticsUniversity of North CarolinaChapel HillUSA

Bibliographic information