Innate Tolerance in the CNS

Translational Neuroprotection by Pre- and Post-Conditioning

  • Jeffrey M. Gidday
  • Miguel A. Perez-Pinzon
  • John H. Zhang

Part of the Springer Series in Translational Stroke Research book series (SSTSR)

Table of contents

  1. Front Matter
    Pages i-ix
  2. Comparative Physiology and Historical Background

    1. Front Matter
      Pages 1-1
    2. Roger Simon
      Pages 3-18
    3. John W. Thompson, Göran E. Nilsson, Miguel A. Perez-Pinzon
      Pages 19-35
    4. Kelly L. Drew, Jeffrey A. Zuckerman, Phillip E. Shenk, Lori K. Bogren, Tulasi R. Jinka, Jeanette T. Moore
      Pages 37-50
    5. Derek J. Hausenloy, Derek M. Yellon
      Pages 51-101
  3. Conditioning Methods

    1. Front Matter
      Pages 103-103
    2. Ryan Kochanski, David Dornbos III, Yuchuan Ding
      Pages 105-131
    3. Robert D. Gilchrist, Jeffrey M. Gidday
      Pages 183-212
    4. Jian Guan, Richard F. Keep, Ya Hua, Karin M. Muraszko, Guohua Xi
      Pages 213-224
    5. Giuseppe Pignataro, Ornella Cuomo, Antonio Vinciguerra
      Pages 225-240
  4. Conditioning Models for Cerebral Ischemia

    1. Front Matter
      Pages 241-241
    2. Nicole M. Jones, Adam A. Galle
      Pages 259-268
    3. Robert P. Ostrowski, John H. Zhang
      Pages 291-308
    4. Richard F. Keep, Ya Hua, Guohua Xi
      Pages 309-316
  5. Mechanisms of Preconditioning

    1. Front Matter
      Pages 337-337
    2. Robert Meller
      Pages 339-361
    3. Keri B. Vartanian, Susan L. Stevens, Mary P. Stenzel-Poore
      Pages 363-386
    4. Peiying Li, Rehana Leak, Yu Gan, Xiaoming Hu, R. Anne Stetler, Jun Chen
      Pages 387-427
    5. Srinivasan Narayanan, Jake T. Neumann, Kahlilia C. Morris-Blanco, Miguel A. Perez-Pinzon, Hung Wen Lin
      Pages 429-455
  6. Other Neurological Disorders

    1. Front Matter
      Pages 483-483
    2. Cherine H. Kim, Han Chen, John H. Zhang
      Pages 485-498
    3. Esther Shohami, Michal Horowitz
      Pages 499-519
    4. David C. Henshall, Eva M. Jimenez-Mateos
      Pages 521-539
    5. Steven Roth, John C. Dreixler
      Pages 541-550
  7. Clinical Applications

    1. Front Matter
      Pages 551-551
    2. Qiang Wang, Lize Xiong
      Pages 579-589
    3. Qiang Wang, Lize Xiong
      Pages 591-599
    4. Michael Katsnelson, Sebastian Koch
      Pages 601-613
  8. Back Matter
    Pages 615-699

About this book


Cerebral ischemia from cardiac arrest, stroke, and subarachnoid and intracerebral hemorrhage, together with trauma, epilepsy, and other CNS pathologies, continue to impose immense burdens of morbidity and mortality the world over. Despite many decades of research aimed at understanding the genetic and molecular basis of these pathologies, therapeutics developed on the basis of blocking ‘known’ injury mechanisms can actually claim few clinical successes. The field of CNS “preconditioning” was born from the preclinical finding more than 20 years ago that intentional activation of innate, cytoprotective factors could provide robust protection, or “tolerance” against cerebral ischemic injury. 

Herein, up-to-date summaries on all aspects of preconditioning for CNS disease, including the emerging topics of postconditioning and remote pre- and post-conditioning, are provided by the leading scientists in the field. The translational potential of both preclinical and clinical advances is underscored throughout, with the hope of accelerating the bench-to-bedside success of endogenous cytoprotection as a therapeutic strategy.


Jeffrey M. Gidday PhD, Associate Professor of Neurosurgery at Washington University School of Medicine, has been working in the field of CNS preconditioning for 18 years, and has numerous publications on preconditioning-induced protection in the setting of several different cerebral and retinal pathologies. 

Miguel A. Perez-Pinzon PhD is Professor of Neurology/Neuroscience, Vice-Chair for Basic Science of Neurology at the University of Miami Miller School of Medicine. He began studies of ischemic preconditioning in 1995 and for many years prior to that worked in the field of anoxia tolerance, publishing close to 50 peer-reviewed articles and many book chapters on these topics.

John H. Zhang MD PhD is Professor of Neurosurgery, Anesthesiology, and Physiology, and Vice-Chair of the Basic Science Department at the Loma Linda University School of Medicine. His research interests include stroke and medical gases, and he has published papers related to pre-, post- and remote-conditioning in subarachnoid hemorrhage, focal cerebral ischemia, and neonatal brain injury.

Editors and affiliations

  • Jeffrey M. Gidday
    • 1
  • Miguel A. Perez-Pinzon
    • 2
  • John H. Zhang
    • 3
  1. 1., Departments of NeurosurgeryWashington University School of MedicineSt. LouisUSA
  2. 2., Department of NeurologyUniversity of Miami Miller School of MedMiamiUSA
  3. 3.Loma Linda UniversityLoma LindaUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media New York 2013
  • Publisher Name Springer, New York, NY
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-1-4419-9694-7
  • Online ISBN 978-1-4419-9695-4
  • Buy this book on publisher's site