© 2012

Metal Ion in Stroke

  • Yang V. Li
  • John H. Zhang

Part of the Springer Series in Translational Stroke Research book series (SSTSR)

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Yang V. Li, John H. Zhang
    Pages 1-12
  3. Calcium (Ca)

    1. Front Matter
      Pages 13-13
    2. Jillian C. Belrose, Fabiana A. Caetano, Kai Yang, Brian M. W. Lockhart, Michael F. Jackson, John F. MacDonald
      Pages 15-39
    3. Maria Josè Sisalli, Claudia Savoia, Antonella Scorziello
      Pages 41-67
    4. Anna Poggesi, Domenico Inzitari
      Pages 69-101
    5. Elena Alberdi, María Domercq, Carlos Matute
      Pages 103-127
  4. Zinc (Zn)

    1. Front Matter
      Pages 165-165
    2. Yang V. Li
      Pages 167-189
    3. Richard B. Thompson
      Pages 209-226
    4. Robert A. Colvin, Christian J. Stork, Yang V. Li, Barry Lai
      Pages 227-237
  5. Iron (Fe)

    1. Front Matter
      Pages 239-239
    2. Chih Ming Lin, Magdy Selim
      Pages 241-253
    3. Dimitrios Galaris, Natalia Kitsati, Sygkliti-Henrietta Pelidou, Alexandra Barbouti
      Pages 255-271
    4. Jin-Yul Lee, Richard F. Keep, Ya Hua, Aditya Pandey, Guohua Xi
      Pages 273-282
    5. Mónica Millán, Natalia Pérez de la Ossa, Teresa Gasull
      Pages 283-301
  6. Sodium (Na)

    1. Front Matter
      Pages 303-303
    2. Mauro Cataldi, Pasquale Molinaro, Lucio Annunziato
      Pages 305-331

About this book


This book illustrates remarkable roles of metal ions in the neuropathophysiology of stroke, which is a major cause of death and disability worldwide. Metal ions have unique chemical properties that allow them to play diverse roles in the brain. They regulate excitability and function as co-factors in cellular and genetic signaling pathways and therefore, have important roles ranging from essential to toxic. For the first time, the dyshomeostasis and pathophysiological actions of these metals in stroke are discussed systematically in thirty-six chapters in one volume.


Highlighted metal ions include:

Aluminum (Al)

Arsenic (As)

Cadmium (Cd)

Calcium (Ca)

Copper (Cu)

Iron (Fe)

Magnesium (Mg)

Manganese (Mn)

Mercury (Hg)

Nickel (Ni)

Potassium (K)

Selenium (Se)

Sodium (Na)

Zinc (Zn)

Editors and affiliations

  • Yang V. Li
    • 1
  • John H. Zhang
    • 2
  1. 1., Department of Biomedical SciencesOhio UniversityAthensUSA
  2. 2.Loma Linda UniversityLoma LindaUSA

Bibliographic information

  • Book Title Metal Ion in Stroke
  • Editors Yang V. Li
    John H. Zhang
  • Series Title Springer Series in Translational Stroke Research
  • DOI
  • Copyright Information Springer Science+Business Media New York 2012
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-1-4419-9662-6
  • Softcover ISBN 978-1-4939-4149-0
  • eBook ISBN 978-1-4419-9663-3
  • Edition Number 1
  • Number of Pages XVII, 820
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Neurosciences
  • Buy this book on publisher's site


From the reviews:

“This is a comprehensive book about the role of ions and anions in neurotransmission, cerebral ischemia, subarachnoid hemorrhage, trauma etc. Each chapter is devoted to the indication of mediators related to channel and mitochondrial pathophysiology. … I recommend this book to neurologists, neurosurgeons, biochemists, and neurophysiologists. Students will be greatly helped by this book, showing that cofactors can be toxic, but at micromolar ranges be beneficial to the stroked brain in small vessel disease.” (Joseph J. Grenier,, May, 2014)