Metal Ion in Stroke

  • Yang V. Li
  • John H. Zhang
Book

Part of the Springer Series in Translational Stroke Research book series (SSTSR)

Table of contents

  1. Front Matter
    Pages i-xvii
    PDF
  2. Metal Ions in Stroke Pathophysiology
    Yang V. Li, John H. Zhang
    Pages 1-12

  3. Calcium (Ca)

    1. Front Matter
      Pages 13-13
      PDF
    2. Mechanisms of Calcium Influx Following Stroke
      Jillian C. Belrose, Fabiana A. Caetano, Kai Yang, Brian M. W. Lockhart, Michael F. Jackson, John F. MacDonald
      Pages 15-39
    3. Mitochondrial Ca2+ Dysregulation During Stroke and Cell Death
      Maria Josè Sisalli, Claudia Savoia, Antonella Scorziello
      Pages 41-67
    4. Calcium Channel Blockers and Stroke Prevention
      Anna Poggesi, Domenico Inzitari
      Pages 69-101
    5. Calcium Dyshomeostasis in Astrocytes After Ischemia
      Elena Alberdi, María Domercq, Carlos Matute
      Pages 103-127
    6. Calcium Signaling at the Blood–Brain Barrier in Stroke
      Rachel C. Brown
      Pages 129-163

  4. Zinc (Zn)

    1. Front Matter
      Pages 165-165
      PDF
    2. Zinc Overload in Stroke
      Yang V. Li
      Pages 167-189
    3. Intracellular Zinc Liberation: A Trigger for Oxidative Stress-Induced Toxicity to Neurons and Neuroglia
      Yumin Zhang
      Pages 191-208
    4. Zinc in Stroke: Time for a New Approach?
      Richard B. Thompson
      Pages 209-226
    5. Exploring the Zinc Metallome of Cultured Cortical Neurons Using Synchroton Radiation X-Ray Fluorescence Microscopy
      Robert A. Colvin, Christian J. Stork, Yang V. Li, Barry Lai
      Pages 227-237

  5. Iron (Fe)

    1. Front Matter
      Pages 239-239
      PDF
    2. Iron Neurotoxicity in Ischemic and Hemorrhagic Stroke
      Chih Ming Lin, Magdy Selim
      Pages 241-253
    3. Implication of Oxidative Stress and “Labile Iron” in the Molecular Mechanisms of Ischemic Stroke
      Dimitrios Galaris, Natalia Kitsati, Sygkliti-Henrietta Pelidou, Alexandra Barbouti
      Pages 255-271
    4. The Role of Iron in Brain Following Subarachnoid Hemorrhage
      Jin-Yul Lee, Richard F. Keep, Ya Hua, Aditya Pandey, Guohua Xi
      Pages 273-282
    5. Iron-Chelating Therapy in Stroke
      Mónica Millán, Natalia Pérez de la Ossa, Teresa Gasull
      Pages 283-301

  6. Sodium (Na)

    1. Front Matter
      Pages 303-303
      PDF
    2. The Role of Na+/Ca2+ Countertransport and Other Na+-Entry Routes in the Pathophysiology of Stroke
      Mauro Cataldi, Pasquale Molinaro, Lucio Annunziato
      Pages 305-331

About this book

Introduction

This book illustrates remarkable roles of metal ions in the neuropathophysiology of stroke, which is a major cause of death and disability worldwide. Metal ions have unique chemical properties that allow them to play diverse roles in the brain. They regulate excitability and function as co-factors in cellular and genetic signaling pathways and therefore, have important roles ranging from essential to toxic. For the first time, the dyshomeostasis and pathophysiological actions of these metals in stroke are discussed systematically in thirty-six chapters in one volume.

 

Highlighted metal ions include:

Aluminum (Al)

Arsenic (As)

Cadmium (Cd)

Calcium (Ca)

Copper (Cu)

Iron (Fe)

Magnesium (Mg)

Manganese (Mn)

Mercury (Hg)

Nickel (Ni)

Potassium (K)

Selenium (Se)

Sodium (Na)

Zinc (Zn)

Editors and affiliations

  • Yang V. Li
    • 1
  • John H. Zhang
    • 2
  1. 1., Department of Biomedical SciencesOhio UniversityAthensUSA
  2. 2.Loma Linda UniversityLoma LindaUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4419-9663-3
  • Copyright Information Springer Science+Business Media New York 2012
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-4419-9662-6
  • Online ISBN 978-1-4419-9663-3
  • About this book