Translational Stroke Research

From Target Selection to Clinical Trials

  • Paul A. Lapchak
  • John H. Zhang

Part of the Springer Series in Translational Stroke Research book series (SSTSR)

Table of contents

  1. Front Matter
    Pages i-xxiv
  2. Theoretical Overview

    1. Front Matter
      Pages 1-1
    2. Sara Morales Palomares, Marilyn J. Cipolla
      Pages 3-36
    3. Ken Arai, Loc-Duyen D. Pham, Eng H. Lo
      Pages 57-78
    4. Aarti Sarwal, Muhammad Shazam Hussain, Ashfaq Shuaib
      Pages 79-97
  3. Mechanisms and Targets

    1. Front Matter
      Pages 99-99
    2. Chunli H. Liu, Fan Zhang, Tibor Krisrian, Brian Polster, Gary M. Fiskum, Bingren Hu
      Pages 101-116
    3. Fernanda M. F. Roleira, Elisiário J. Tavares-da-Silva, Jorge Garrido, Fernanda Borges
      Pages 117-143
    4. Ruoyang Shi, Jiequn Weng, Paul Szelemej, Jiming Kong
      Pages 145-174
    5. Chunhua Chen, Changman Zhou
      Pages 175-188
    6. Frances Rena Bahjat, Keri B. Vartanian, G. Alexander West, Mary P. Stenzel-Poore
      Pages 205-230
    7. Jieli Chen, Michael Chopp
      Pages 231-249
    8. Ihsan Solaroglu, Murat Digicaylioglu
      Pages 251-276
    9. Jonathan W. Nelson, Nabil J. Alkayed
      Pages 277-294
    10. Jens P. Dreier, Maren Winkler, Dirk Wiesenthal, Michael Scheel, Clemens Reiffurth
      Pages 295-303
    11. Masaaki Hokari, Midori A. Yenari
      Pages 305-320
    12. Liren Qian, Prativa Sherchan, Xuejun Sun
      Pages 321-334
    13. Ashutosh Dharap, Venkata P. Nakka, Raghu Vemuganti
      Pages 335-352
    14. Zhanyang Yu, Ning Liu, Xiaoying Wang
      Pages 353-372
    15. Pamela Maher, Alain César Biraboneye, Jean-Louis Kraus
      Pages 373-385
    16. Ya Hua, Richard F. Keep, Yuxiang Gu, Guohua Xi
      Pages 403-416
  4. Translational Models

  5. De-Risking of Drug Candidates

  6. Therapy Delivery

    1. Front Matter
      Pages 657-657
  7. Therapy Development

    1. Front Matter
      Pages 689-689
    2. Marta Rubiera, Carlos A. Molina
      Pages 745-752
    3. Thilo Hölscher, Golnaz Ahadi, Daniel Lotz, Cheryl Schendel, David Fisher, Arne Voie
      Pages 753-776
    4. Todd Deveau, Shan Ping Yu, Ling Wei
      Pages 777-814
  8. Clinical Trial Design

    1. Front Matter
      Pages 815-815
    2. Steven C. Cramer
      Pages 817-831
    3. Pitchaiah Mandava, Chase S. Krumpelman, Santosh B. Murthy, Thomas A. Kent
      Pages 833-861
    4. Krishna A. Dani, Keith W. Muir
      Pages 863-879
    5. Nirmalya Ghosh, Yu Sun, Christine Turenius, Bir Bhanu, Andre Obenaus, Stephen Ashwal
      Pages 881-909

About this book


Translational Stroke Research: From Target Selection to Clinical Trials is part of “Springer Series in Translational Stroke Research.” Forty-three chapters from leading stroke research groups around the world select future targets and methods for stroke management such as the vasculature and white matter, protein aggregation, neuroglobin, microRNAs, oxidation, soluble epoxide hydrolase, apoptosis, hypoxia-inducible factors, thrombin, toll-like receptor, angiogenesis, membrane potentials and pumps. The book discusses methods to regulate brain temperature and the use of preconditioning in stroke. It also presents new areas of research emphasizing restoration of function with growth factors and stem cells.  It provides multiple animal models of both ischemic and hemorrhagic stroke in order to translate basic preclinical findings to clinical trials with de-risking issues,  therapy delivery methods such as sustained-release and intranasal delivery, and potential therapies including cell therapies, albumin, transcranial laser, microbubbles, and ultrasound. Finally, it debates clinical trial design for analytical methodology, imaging, computation, and innovations.

Editors and affiliations

  • Paul A. Lapchak
    • 1
  • John H. Zhang
    • 2
  1. 1., Department of NeurologyCedars-Sinai Medical CenterLos AngelesUSA
  2. 2.Loma Linda UniversityLoma LindaUSA

Bibliographic information