Table of contents

  1. Front Matter
    Pages i-xviii
  2. Tim Eden
    Pages 1-24
  3. Shekhar Krishnan, Ashish Masurekar, Vaskar Saha
    Pages 25-37
  4. Barbara Szymanska, Hernan Carol, Richard B. Lock
    Pages 39-60
  5. James A. Whitlock, Terzah M. Horton
    Pages 61-81
  6. Maria Grazia Valsecchi, Paola De Lorenzo
    Pages 83-104
  7. Michael A. Batey, Josef H. Vormoor
    Pages 105-115
  8. Guy Makin, Caroline Dive
    Pages 117-141
  9. Clare Pridans, Brian J. P. Huntly
    Pages 143-166
  10. Pamela Kearns, Vaskar Saha
    Pages 167-187
  11. Joya Chandra, Claudia P. Miller
    Pages 273-298
  12. Pamela Kearns
    Pages 299-310
  13. Paul S. Gaynon, Theresa M. Harned
    Pages 311-327
  14. Back Matter
    Pages 329-338

About this book

Introduction

New Agents for the Treatment of Acute Lymphoblastic Leukaemia (ALL), examines the strategies for the use of new agents as well as possible targets of therapy in this disease. Though associated with high cure rates, relapsed disease has a poor outcome. Moreover, therapy is unduly prolonged and toxic. For over 4 decades, no new drugs have been available and now we have a surfeit. The challenge is to design trials to evaluate the potential efficacy of non-targeted therapy in a disease with good outcome. An increasing number of pathways, amenable to targeted therapy are also being identified. The heterogeneity of ALL suggests that targeted therapy at the moment will need to be tailored to the patient. How then can such drugs be evaluated within conventional clinical trials? These are the crossroads we have reached in acute lymphoblastic leukaemia and this book discusses and proposes some solutions to these issues.

Keywords

Cancer Leukaemia Leukemia Lymphoma Treatment

Editors and affiliations

  • Vaskar Saha
    • 1
  • Pamela Kearns
    • 2
  1. 1.Christie Hospital, Dept. Paediatric & Adolescent OncologyUniversity of ManchesterManchesterUnited Kingdom
  2. 2., School of Cancer SciencesUniversity of BirminghamEdgbaston, BirminghamUnited Kingdom

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4419-8459-3
  • Copyright Information Springer Science+Business Media, LLC 2011
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-4419-8458-6
  • Online ISBN 978-1-4419-8459-3
  • About this book