Pathophysiology, Diagnosis, and Treatment

  • Christian R. Baumann
  • Claudio L. Bassetti
  • Thomas E. Scammell

Table of contents

  1. Front Matter
    Pages i-xv
  2. Etiology of Narcolepsy

    1. Front Matter
      Pages 1-1
    2. Emmanuel Mignot
      Pages 3-17
    3. Adriano Fontana, Heidemarie Gast, Thomas Birchler
      Pages 19-26
    4. Christelle Peyron
      Pages 27-33
  3. Neurochemistry of Narcolepsy

    1. Front Matter
      Pages 35-35
    2. Chloé Alexandre, Thomas E. Scammell
      Pages 73-84
    3. Yoshihiro Urade, Osamu Hayaishi
      Pages 93-104
  4. The Role of the Hypocretins in Sleep–Wake Regulation

    1. Front Matter
      Pages 105-105
    2. Pierre-Hervé Luppi, Patrice Fort
      Pages 107-119
    3. Matthew E. Carter, Antoine Adamantidis, Luis de Lecea
      Pages 121-128
    4. Antoine Adamantidis, Luis de Lecea
      Pages 129-137
    5. Christopher S. Leonard, Mike Kalogiannis, Kristi A. Kohlmeier
      Pages 139-151
    6. Thomas S. Kilduff, Junko Hara, Takeshi Sakurai, Xinmin Xie
      Pages 153-162
    7. Thomas E. Scammell, Chloé Alexandre
      Pages 163-174
    8. Cecilia Diniz Behn
      Pages 175-187
  5. The Key Role of the Hypothalamus

    1. Front Matter
      Pages 189-189
    2. Giovanna Zoccoli, Roberto Amici, Alessandro Silvani
      Pages 191-203
    3. Thomas Pollmächer, Marietta Keckeis, Andreas Schuld
      Pages 217-225
    4. Alice Engel, Norbert Dahmen
      Pages 227-237
  6. Reward, Addiction, Emotions and the Hypocretin System

    1. Front Matter
      Pages 239-239
    2. Ralph J. DiLeone, Maysa Sarhan, Ruth Sharf
      Pages 253-260
    3. Sophie Schwartz
      Pages 261-270
    4. Michael Lutter
      Pages 271-279
  7. REM Sleep Dysregulation and Motor Abnormalities in Narcolepsy

    1. Front Matter
      Pages 281-281
    2. Sebastiaan Overeem
      Pages 283-290
    3. Yves Dauvilliers, Régis Lopez
      Pages 291-299
  8. The Borderlands of Narcolepsy

    1. Front Matter
      Pages 307-307
    2. Claudio L. Bassetti
      Pages 309-319
    3. Philipp O. Valko, Rositsa Poryazova
      Pages 321-339
    4. Christian R. Baumann, Rositsa Poryazova
      Pages 341-346
    5. Ramin Khatami
      Pages 357-366
  9. The Diagnosis of Narcolepsy and the Assessment of Fitness to Drive

    1. Front Matter
      Pages 367-367
    2. Johannes Mathis
      Pages 389-398
  10. Treatment of Narcolepsy

    1. Front Matter
      Pages 399-399
    2. G. J. Lammers
      Pages 401-409
    3. Michel Lecendreux
      Pages 411-417
  11. Back Matter
    Pages 419-428

About this book


The field of narcolepsy has developed enormously within the last 10 years. Indeed the understanding of the basics of sleep-wake regulation and the discovery of new neurotransmitter systems (the hypocretins) has boosted research and key findings in the field, providing important insights into how sleep is regulated. Consequently narcolepsy now receives a great deal of attention from both clinicians and scientists throughout the world. Narcolepsy: Pathophysiology, Diagnosis, and Treatment not only offers an engaging and comprehensive treatment of a fascinating disorder but also includes a DVD that offers a unique and large collection of movies displaying the symptoms of narcolepsy in people and animals. Written by some of the best experts in the field, the book focuses on the pathophysiology of the problem and also provides critical, up-to-date insights on the key clinical issues: how to diagnose the disorder, how to treat it, and how to best manage psychosocial problems. The first and only guide to span the latest advances in narcolepsy, this reference provides sections in etiology, neurochemistry, the role of the hypocretins in sleep-wake regulation, animal models in narcolepsy, the key role of the hypothalamus, REM-sleep dysregulation, diagnosis and classification, and treatment. Compiled by an international group of more than 30 authors, Narcolepsy: Pathophysiology, Diagnosis, and Treatment is an indispensable resource for all clinicians and scientists with an interest in narcolepsy.


Addiction Appetite Autonomic Dopamine Hypersomnia Hypocretins Hypothalamus Metabolic regulation Narcolepsy Neurochemistry Obesity REM Reward Sleep-wake regulation

Editors and affiliations

  • Christian R. Baumann
    • 1
  • Claudio L. Bassetti
    • 2
  • Thomas E. Scammell
    • 3
  1. 1., Department of NeurologyUniversity Hospital of ZurichZurichSwitzerland
  2. 2.Neurocenter EOC of Southern Switzerland, Department of NeurologyUniversity Hospital ZurichLuganoSwitzerland
  3. 3.and Harvard Medical School, Department of NeurologyBeth Israel Deaconess Medical CenterBostonUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC 2011
  • Publisher Name Springer, New York, NY
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-1-4419-8389-3
  • Online ISBN 978-1-4419-8390-9
  • Buy this book on publisher's site