© 2011


Non-Linear Phenomena and Drug Product Development


Part of the Outlines in Pharmaceutical Sciences book series (OIPS, volume 1)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Anthony J. Hickey, Hugh D. C. Smyth
    Pages 1-4
  3. Anthony J. Hickey, Hugh D. C. Smyth
    Pages 5-18
  4. Anthony J. Hickey, Hugh D. C. Smyth
    Pages 37-45
  5. Anthony J. Hickey, Hugh D. C. Smyth
    Pages 47-54
  6. Anthony J. Hickey, Hugh D. C. Smyth
    Pages 55-59
  7. Anthony J. Hickey, Hugh D. C. Smyth
    Pages 61-66
  8. Back Matter
    Pages 67-71

About this book


The historical approach to the interpretation of physical, chemical and biological phenomena has been to consider relationships with causative factors that can be reduced to linearity allowing simple and direct interpretation. However, it is increasingly evident that there is often more information in the data than linear interpretations allow. The current capacity for computers to assist in identifying non-linear relationships allows greater interpretation of data which illuminates the phenomena allowing the information to be translated into knowledge that can be used wisely to promote various desirable pharmaceutical outcomes. This short volume is intended to stimulate the reader to contemplate research and development areas in which the data might be more accurately interpreted to allow greater understanding and ultimately control of the pharmaceutically complex phenomena.


Complexity Development Drug Hickey Pharmaco Phenomena Product Smyth

Authors and affiliations

  1. 1.Eshelman School of Pharmacy, Division of Molecular PharmaceuticsUniversity of North CarolinaChapel HillUSA
  2. 2., Pharmaceutics Division - PHR 4.214University of TexasAustinUSA

About the authors

Dr. Anthony Hickey is Professor of Molecular Pharmaceutics and Biomedical Engineering at the University of North Carolina at Chapel Hill. He is a fellow of the Institute of Biology, American Association of Pharmaceutical Scientists and the American Association for the Advancement of Science. He has published several edited and authored volumes in the fields of pharmaceutical aerosols, process engineering and particulate science.

Dr. Hugh Smyth is Assistant Professor of Pharmaceutics at the University of Texas, Austin. He is a recipient of the Young Investigator in Pharmaceutics and Pharmaceutical Technology Award of the American Association of Pharmaceutical Scientists and has edited a volume on pulmonary drug delivery. Drs. Hickey and Smyth share a research interest in the delivery of drugs to the lungs for the treatment and prevention of a number of diseases.

Bibliographic information

  • Book Title Pharmaco-Complexity
  • Book Subtitle Non-Linear Phenomena and Drug Product Development
  • Authors Anthony J. Hickey
    Hugh D.C. Smyth
  • Series Title Outlines in Pharmaceutical Sciences
  • Series Abbreviated Title Outlines in Pharmaceutical
  • DOI
  • Copyright Information American Association of Pharmaceutical Sientists 2011
  • Publisher Name Springer, Boston, MA
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Softcover ISBN 978-1-4419-7855-4
  • eBook ISBN 978-1-4419-7856-1
  • Series ISSN 2191-3188
  • Series E-ISSN 2191-3196
  • Edition Number 1
  • Number of Pages VIII, 71
  • Number of Illustrations 7 b/w illustrations, 2 illustrations in colour
  • Topics Pharmacology/Toxicology
    Biochemistry, general
  • Buy this book on publisher's site