The Fundamentals of Modern Statistical Genetics

  • Nan M. Laird
  • Christoph Lange

Part of the Statistics for Biology and Health book series (SBH)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Nan M. Laird, Christoph Lange
    Pages 15-30
  3. Nan M. Laird, Christoph Lange
    Pages 31-43
  4. Nan M. Laird, Christoph Lange
    Pages 87-97
  5. Nan M. Laird, Christoph Lange
    Pages 99-124
  6. Nan M. Laird, Christoph Lange
    Pages 125-137
  7. Nan M. Laird, Christoph Lange
    Pages 139-159
  8. Nan M. Laird, Christoph Lange
    Pages 161-174
  9. Nan M. Laird, Christoph Lange
    Pages 175-189
  10. Nan M. Laird, Christoph Lange
    Pages 191-192
  11. Back Matter
    Pages 193-223

About this book

Introduction

This book covers the statistical models and methods that are used to understand human genetics, following the historical and recent developments of human genetics. Starting with Mendel’s first experiments to genome-wide association studies, the book describes how genetic information can be incorporated into statistical models to discover disease genes. All commonly used approaches in statistical genetics (e.g. aggregation analysis, segregation, linkage analysis, etc), are used, but the focus of the book is modern approaches to association analysis. Numerous examples illustrate key points throughout the text, both of Mendelian and complex genetic disorders. The intended audience is statisticians, biostatisticians, epidemiologists and quantitatively- oriented geneticists and health scientists wanting to learn about statistical methods for genetic analysis, whether to better analyze genetic data, or to pursue research in methodology. A background in intermediate level statistical methods is required. The authors include few mathematical derivations, and the exercises provide problems for students with a broad range of skill levels. No background in genetics is assumed. Dr. Laird is a Professor of Biostatistics in the Biostatistics Department at the Harvard School of Public Health. Dr. Laird has contributed to methodology in many different fields, including missing data, EM-algorithm, meta-analysis, statistical genetics, and has coauthored a book with Garrett Fitzmaurice and James Ware on Applied Longitudinal Analysis. She is the recipient of many awards and prizes, including Fellow of the American Statistical Association, the American Association for the Advancement of Science, the Florence Nightingale Award, and the Janet Norwood Award. Dr. Lange is an Associate Professor in the Biostatistics Department at the Harvard School of Public Health. After his PhD in Statistics at the University of Reading (UK), he has worked extensively in the field of statistical genetics. Dr. Lange has been the director of the Institute of Genome Mathematics at the University of Bonn and has received several awards in mathematics and genetics. Dr. Lange is the developer of the PBAT package.

Keywords

Gene Mapping Genome Wide Association Studies Statistical Genetics

Authors and affiliations

  • Nan M. Laird
    • 1
  • Christoph Lange
    • 1
  1. 1.Department of BiostatisticsHarvard UniversityBostonUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4419-7338-2
  • Copyright Information Springer Science+Business Media, LLC 2011
  • Publisher Name Springer, New York, NY
  • eBook Packages Mathematics and Statistics
  • Print ISBN 978-1-4419-7337-5
  • Online ISBN 978-1-4419-7338-2
  • Series Print ISSN 1431-8776
  • Series Online ISSN 2197-5671
  • About this book