Molecular Defects in Cardiovascular Disease

  • Naranjan S. Dhalla
  • Makoto Nagano
  • Bohuslav Ostadal

Table of contents

  1. Front Matter
    Pages i-xviii
  2. Molecular Mechanisms in Heart Disease

    1. Front Matter
      Pages 1-1
    2. Yaser Cheema, Atta U. Shahbaz, Syamal K. Bhattacharya, Robert A. Ahokas, Yao Sun, Ivan C. Gerling et al.
      Pages 3-15
    3. Nermeen Youssef, Richard Schulz
      Pages 17-28
    4. Ryan H. Cunnington, Josette M. Douville, Jeffrey T. Wigle, Darren H. Freed, Dedmer Schaafsma, Sarah O’Connor et al.
      Pages 29-42
    5. Bohuslav Ostadal, I. Ostadalova, F. Kolar, I. Netuka, O. Szarszoi
      Pages 55-67
    6. Partha Mukhopadhyay, Narasimman Gurusamy, Dipak K. Das
      Pages 69-81
    7. Dinender K. Singla
      Pages 83-91
  3. Cardiac Hypertrophy and Heart Failure

    1. Front Matter
      Pages 93-93
    2. Jiazhen M. Dai, Michael F. Allard
      Pages 127-140
    3. Jagdip S. Jaswal, Wendy Keung, Wei Wang, John R. Ussher, Gary D. Lopaschuk
      Pages 153-175
    4. Stefan Hein, Sawa Kostin, Jutta Schaper
      Pages 197-214
    5. Andrea P. Babick, Vijayan Elimban, Naranjan S. Dhalla
      Pages 215-229
  4. Hypertension and Diabetes

    1. Front Matter
      Pages 257-257
    2. Binil Raj, Harikrishnan Sivadasanpillai, Chandrasekharan Cheranellore Kartha
      Pages 259-271
    3. Raissa Perrault, Peter Zahradka
      Pages 283-303
    4. Shilpa Kshatriya, Hani Kozman, Danish Siddiqui, Luna Bhatta, Kan Liu, Ali Salah et al.
      Pages 343-351
    5. Himanshu Vashistha, Leonard G. Meggs, Ashwani Malhotra
      Pages 353-363
  5. Back Matter
    Pages 379-382

About this book


Molecular Defects in Cardiovascular Disease provides an in-depth discussion of the molecular mechanisms underlying the genesis of cardiovascular defects and the implications this has on current and emerging targeted therapeutics.  Divided into three sections, this book covers the scientific foundations of our present understanding as well as the array of clinical manifestations and their treatment.  The first section covers Molecular Mechanisms of Heart Disease, with discussion of the development of cardiovascular dysfunction.  The remaining two sections provide a more clinical focus.  The second, Cardiac Hypertrophy and Heart Failure deals with metabolic derangements, Ca2+ handling, and subcellular remodeling.  It illustrates the wide variety of molecular defects which may serve as targets associated with the transition from cardiac hypertrophy to advanced heart failure.  The third section, Hypertension and Diabetes, provides molecular rationale for the pathogenesis of hypertension and diabetic cardiomyopathy, as well as highlighting the importance of hormones toward this end. 


A necessary resource for clinicians and researchers, this book elucidates the experimental basis of the practice of cardiology.  It is the culmination of our advances in the understanding of cardiovascular molecular biology and a blueprint for the efficacious use of targeted therapies.


Cardiac Cardiovascular Genes Genetics Heart

Editors and affiliations

  • Naranjan S. Dhalla
    • 1
  • Makoto Nagano
    • 2
  • Bohuslav Ostadal
    • 3
  1. 1.St. Boniface General Hospital, Research CentreInstitute of Cardiovascular SciencesWinnipegCanada
  2. 2.Jikei University School of MedicineTokyoJapan
  3. 3.Czech Republic, Institute of PhysiologyAcademy of Sciences of thePragueCzech Republic

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC 2011
  • Publisher Name Springer, New York, NY
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-1-4419-7129-6
  • Online ISBN 978-1-4419-7130-2
  • Buy this book on publisher's site