Obesity Before Birth

Maternal and prenatal influences on the offspring

  • Robert H Lustig

Part of the Endocrine Updates book series (ENDO, volume 30)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Genetic Disorders Leading to Obesity

    1. Front Matter
      Pages 23-23
    2. Robert H. Lustig
      Pages 1-22
  3. Genetic disorders leading to obesity

    1. Front Matter
      Pages 23-23
    2. Johanna C. Andersson, Andrew J. Walley
      Pages 25-52
    3. Ivy R. Aslan, Sayali A. Ranadive, Christian Vaisse
      Pages 53-69
    4. David S. Parker, Nicholas Katsanis
      Pages 71-93
    5. Ruth J.F. Loos, Tuomas O. Kilpeläinen
      Pages 95-112
  4. Epigenetic changes and the development of obesity

  5. Developmental programming and the development of obesity

    1. Front Matter
      Pages 191-191
    2. Naomi E. Stotland, Janet C. King
      Pages 205-214
    3. Michael G. Ross, Ivan Huber, Mina Desai
      Pages 215-239
    4. Larissa Jane Prior, Geoffrey Albert Head, James Andrew Armitage
      Pages 241-259
    5. Amanda J. Drake, Jonathan R. Seckl
      Pages 279-300
    6. Clement C. Cheung, Holly A. Ingraham
      Pages 301-319
    7. Elvira Isganaitis, Mary-Elizabeth Patti
      Pages 321-352
  6. Environmental obesogens

  7. Back Matter
    Pages 401-412

About this book


Obesity obeys the First Law of Thermodynamics. The routine assumption is that obesity is the result of a mismatch between calories in and calories out; in other words, the result of two divergent behaviors. However, there is mounting evidence that biochemical forces can drive obligate weight gain, and that the observed behaviors of increased energy intake and decreased energy expenditure are secondary to these processes. Furthermore, many of these biochemical forces are determined in utero; resulting in a developmental drive toward obesity and disease in later life. Four distinct prenatal forces have thus far been identified: 1) genetics; 2) epigenetics; 3) developmental programming; and 4) environmental obesogens. This volume explores the evidence for each of these in detail in human and animal models, and attempts to provide a cohesive analysis of the biochemical bases of obesity. This volume will appeal to geneticists, developmental biologists, endocrinologists, epidemiologists, toxicologists, obstetrician/gynecologists, nutritionists, veterinary scientists, animal husbandry researchers, domestic species researchers, and obesity researchers and practitioners. "This very timely volume provides an in-depth scholarly overview of a critical challenge facing our society—the obesity epidemic. Dr. Robert H. Lustig has assembled expert authors to address the fundamental contribution of preprogrammed genetic disorders leading to obesity, as well as the role of very early environmental influences. The chapters range from classic genetic mechanistic understanding through intra-uterine epigenetic influences, factors determining developmental programming, and the new clinical science of perinatal obesogens. Obesity Before Birth: Maternal and prenatal influences on the offspring, brings easily accessible, cutting edge information to geneticists, pediatricians, endocrinologists, as well as those clinicians and scientists pursuing the complex yet elusive causes of childhood obesity and related disorders." - Shlomo Melmed, M.D. Series Editor


GNAS locus Obesity Prader-Willi Syndrome clinical obesity obesity risk

Editors and affiliations

  • Robert H Lustig
    • 1
  1. 1.Director, Weight Assessment for Teen and, Division of EndocrinologyUniversity of California, San FranciscoSan FranciscoUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC 2011
  • Publisher Name Springer, Boston, MA
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-1-4419-7033-6
  • Online ISBN 978-1-4419-7034-3
  • Series Print ISSN 1566-0729
  • Buy this book on publisher's site