Protein Metabolism and Homeostasis in Aging

  • Nektarios Tavernarakis

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 694)

Table of contents

  1. Front Matter
    Pages i-xxi
  2. Ranjana Mehta, Devon Chandler-Brown, Fresnida J. Ramos, Lara S. Shamieh, Matt Kaeberlein
    Pages 14-29
  3. Niki Chondrogianni, Efstathios S. Gonos
    Pages 38-46
  4. Kailiang Jia, Beth Levine
    Pages 47-60
  5. Guillermo Mariño, Alvaro F. Fernández, Carlos López-Otín
    Pages 61-68
  6. Tibor Vellai, Krisztina Takács-Vellai
    Pages 69-80
  7. Geert Depuydt, Jacques R. Vanfleteren, Bart P. Braeckman
    Pages 81-107
  8. Karin Luce, Andrea C. Weil, Heinz D. Osiewacz
    Pages 108-125
  9. Florence Debacq-Chainiaux, Emmanuelle Boilan, Jérémie Dedessus Le Moutier, Geoffroy Weemaels, Olivier Toussaint
    Pages 126-137
  10. Elise A. Kikis, Tali Gidalevitz, Richard I. Morimoto
    Pages 138-159
  11. Artemisia M. Andreou, Nektarios Tavernarakis
    Pages 160-171
  12. Joy Alcedo, Wolfgang Maier, Queelim Ch’ng
    Pages 197-210
  13. Manlio Vinciguerra, Antonio Musaro, Nadia Rosenthal
    Pages 211-233
  14. Back Matter
    Pages 245-249

About this book

Introduction

Aging is loosely defined as the accumulation of changes in an organism over time. At the cellular level such changes are distinct and multidimensional: DNA replication ceases, cells stop dividing, they become senescent and eventually die. DNA metabolism and chromosomal maintenance, together with protein metabolism are critical in the aging process. The focus of this book is on the role of protein metabolism and homeostasis in aging. An overview is provided of the current knowledge in the area, including protein synthesis, accuracy and repair, post-translational modifications, degradation and turnover, and how they define and influence aging. The chapters mainly focus on well-characterised factors and pathways, but new areas are also presented, where associations with aging are just being elucidated by current experimental data. Protein turnover, the balance between protein synthesis and protein degradation are carefully maintained in healthy cells. Chapters 1 and 2 illustrate that aging cells are characterised by alterations in the rate, level and accuracy of protein synthesis compared to young ones, and that mRNA translation, essential for cell growth and survival, is controlled at multiple levels. The theory that growth and somatic maintenance are believed to be antagonistic processes is described in Chapter 3: inhibition of protein synthesis results in decreased rates of growth and development, but also confers an extension of lifespan, as shown for example by the effects of dietary restriction in various models organisms.

Keywords

Aging Homeostasis Metabolism Protein Tavernarakis insulin signal transduction

Editors and affiliations

  • Nektarios Tavernarakis
    • 1
  1. 1.Institute of Molecular Biology and Biotechnology (IMBB)Foundation for Research and Technology Hellas (FORTH)CreteGreece

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4419-7002-2
  • Copyright Information Landes Bioscience and Springer Science+Business Media, LLC 2010
  • Publisher Name Springer, Boston, MA
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-4419-7001-5
  • Online ISBN 978-1-4419-7002-2
  • Series Print ISSN 0065-2598
  • About this book