Book Volume 2 2011

BetaSys

Systems Biology of Regulated Exocytosis in Pancreatic ß-Cells

ISBN: 978-1-4419-6955-2 (Print) 978-1-4419-6956-9 (Online)

Table of contents (23 chapters)

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  1. Front Matter

    Pages i-xviii

  2. Systems biology approach to β-cells

    1. Front Matter

      Pages 1-1

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      Chapter

      Pages 3-23

      Systems Biology of the β-Cell – Revisited

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      Chapter

      Pages 25-52

      Established Facts and Open Questions of Regulated Exocytosis in β-Cells – A Background for a Focused Systems Analysis Approach

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      Chapter

      Pages 53-71

      Mitochondria and Metabolic Signals in β-Cells

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      Chapter

      Pages 73-81

      β-Cell Ontogenesis and the Insulin Production Apparatus

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      Chapter

      Pages 83-95

      The Role of the Cytoskeleton in Transport and Release of Insulin-Containing Granules by Pancreatic β-Cells

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      Chapter

      Pages 97-118

      The Mathematical Microscope – Making the Inaccessible Accessible

  3. Imaging and sensors

    1. Front Matter

      Pages 119-119

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      Chapter

      Pages 121-146

      Magnetic Resonance Imaging of Pancreatic β-Cells

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      Chapter

      Pages 147-183

      Mapping the β-Cell in 3D at the Nanoscale Using Novel Cellular Electron Tomography and Computational Approaches

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      Chapter

      Pages 185-220

      In Vivo Applications of Inorganic Nanoparticles

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      Chapter

      Pages 221-240

      Cell Cultivation and Sensor-Based Assays for Dynamic Measurements of Cell Vitality

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      Chapter

      Pages 241-271

      Bioimpedance Spectroscopy

  4. Genetics and proteomics

    1. Front Matter

      Pages 273-273

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      Chapter

      Pages 275-297

      DNA Variations, Impaired Insulin Secretion and Type 2 Diabetes

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      Chapter

      Pages 299-326

      Genetically Programmed Defects in β-Cell Function

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      Chapter

      Pages 327-362

      Proteomic Analysis of the Pancreatic Islet β-Cell Secretory Granule : Current Understanding and Future Opportunities

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      Chapter

      Pages 363-386

      Physiological and Pathophysiological Role of Islet Amyloid Polypeptide (IAPP , Amylin )

  5. Physiological, pharmaceutical and clinical applications and perspectives

    1. Front Matter

      Pages 387-387

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      Chapter

      Pages 389-405

      Present State of Islet Transplantation for Type 1 Diabetes Patients

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      Chapter

      Pages 407-418

      Predictive Protein Networks and Identification of Druggable Targets in the β-Cell

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      Chapter

      Pages 419-434

      Nanotoxicity

  6. Mathematical modeling and numerical simulation

    1. Front Matter

      Pages 435-435

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      Chapter

      Pages 437-458

      From Silicon Cell to Silicon Human

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      Chapter

      Pages 459-473

      Probing Cellular Dynamics with Mesoscopic Simulations

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