Sperm Chromatin

Biological and Clinical Applications in Male Infertility and Assisted Reproduction

  • Armand Zini
  • Ashok Agarwal

Table of contents

  1. Front Matter
    Pages i-xxii
  2. Human Sperm Chromatin: Structure and Function

    1. Front Matter
      Pages 1-1
    2. Rod Balhorn
      Pages 3-18
    3. Rakesh Sharma, Ashok Agarwal
      Pages 19-44
    4. Rafael Oliva, Judit Castillo
      Pages 45-60
    5. Kenneth Dominguez, Chris D. R. Arca, W. Steven Ward
      Pages 61-68
    6. Andrei Zalensky, Olga Mudrak, Irina Zalenskaya
      Pages 69-80
    7. Justin C. St. John, Bianca St. John
      Pages 81-94
    8. Donovan Chan, Jacquetta Trasler
      Pages 95-106
    9. Tin-Lap Lee, Albert Hoi-Hung Cheung, Owen M. Rennert, Wai-Yee Chan
      Pages 107-121
  3. Laboratory Evaluation of Sperm Chromatin

    1. Front Matter
      Pages 123-123
    2. Jaime Gosálvez, Carmen López-Fernández, José Luís Fernández
      Pages 151-170
    3. Gian Carlo Manicardi, Davide Bizzaro, Denny Sakkas
      Pages 171-179
    4. Igor Tsarev, Juris Erenpreiss
      Pages 181-188
    5. Alex C. Varghese, C. Fischer-Hammadeh, M. E. Hammadeh
      Pages 189-199
    6. Rakesh Sharma, Ashok Agarwal
      Pages 201-215
    7. Luke Simon, Sheena E. M. Lewis
      Pages 217-232
    8. Timothy G. Jenkins, Benjamin R. Emery, Douglas T. Carrell
      Pages 233-241
    9. Cristina Joana Marques, Alberto Barros, Mário Sousa
      Pages 243-257
    10. Jean-Pierre Dadoune, Isabelle Galeraud-Denis, Serge Carreau
      Pages 259-274
  4. Biological and Clinical Determinants of Sperm Chromatin Damage

    1. Front Matter
      Pages 275-275
    2. R. John Aitken, Geoffry N. De Iuliis
      Pages 277-293
    3. Hasan M. El-Fakahany, Denny Sakkas
      Pages 295-306
    4. Marie-Chantal Grégoire, Frédéric Leduc, Guylain Boissonneault
      Pages 307-320
    5. Mona Bungum, Aleksander Giwercman, Marcello Spanò
      Pages 321-335
    6. Fábio F. Pasqualotto, Eleonora B. Pasqualotto
      Pages 337-349
    7. Aleksander Giwercman
      Pages 361-374
    8. Aldo E. Calogero, Sandro La Vignera, Rosita A. Condorelli, Rosario D’Agata, Enzo Vicari
      Pages 375-394
  5. Sperm Chromatin and Assisted Reproductive Technology Outcomes

    1. Front Matter
      Pages 395-395
    2. Dan Yu, Luke Simon, Sheena E. M. Lewis
      Pages 397-409
    3. Steven Fleming, R. John Aitken
      Pages 423-429
    4. Armand Zini, Maria San Gabriel
      Pages 431-440
    5. Armand Zini, Jason Matthew Boman
      Pages 457-463
    6. Miriam Pérez-Crespo, Raúl Fernández-González, Miguel Ángel Ramírez, Eva Pericuesta, Alexandra Calle, Alfonso Gutiérrez-Adán
      Pages 465-478
    7. Armand Zini, Naif Al-Hathal
      Pages 479-484
  6. Protocols and Integrity Tests

    1. Front Matter
      Pages 485-485
    2. Donald P. Evenson
      Pages 487-493
    3. Rakesh Sharma, Ashok Agarwal
      Pages 495-497
  7. Hasan M. El-Fakahany, Moetaz M. El-Domyati, Denny Sakkas
    Pages E1-E1
  8. Back Matter
    Pages 505-512

About this book


Sperm DNA damage is common and has been associated with reduced rates of conception, impaired embryonic development and increased risk of miscarriage. Although the exact causes of sperm DNA damage are unknown, it is clear that infertile men possess substantially higher levels of sperm DNA damage than do fertile men. Written by leading, internationally renowned clinicians and basic scientists with expertise in sperm DNA, Sperm Chromatin: Biological and Clinical Applications in Male Infertility and Assisted Reproduction provides readers with a thoughtful and comprehensive review of the biological and clinical significance of sperm DNA damage. The work covers the fundamental principles of sperm chromatin architecture and function, the proposed modes of DNA damage and repair, the tests of sperm DNA damage, the clinical aspects of DNA damage and the impact of DNA damage on reproductive outcome. Unlike any other title on the topic, Sperm Chromatin: Biological and Clinical Applications in Male Infertility and Assisted Reproduction is an invaluable addition to the literature and will serve as an indispensable resource for basic scientists with an interest in sperm biology and for urologists, gynecologists, reproductive endocrinologists, and embryologists working in the field of infertility.


Assisted reproductive technologies Chromatin DNA DNA repair Histones Male gamete morphogenesis Male infertility Nucleoproteins Protamine Sperm Sperm Epigenome Spermatogenesis Testis

Editors and affiliations

  • Armand Zini
    • 1
  • Ashok Agarwal
    • 2
  1. 1.St. Mary's Hospital, Div. UrologyMcGill UniversityMontrealCanada
  2. 2.Lerner College of Medicine, Center for Reproductive MedicineCleveland ClinicClevelandUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC 2011
  • Publisher Name Springer, New York, NY
  • eBook Packages Medicine
  • Print ISBN 978-1-4419-1781-2
  • Online ISBN 978-1-4419-6857-9
  • Buy this book on publisher's site