Inherited Cancer Syndromes

Current Clinical Management

  • C. Neal Ellis

Table of contents

  1. Front Matter
    Pages i-viii
  2. C. Neal Ellis
    Pages 1-21
  3. Brandie Heald, James M. Church
    Pages 23-33
  4. Roy E. Gandy, Charles B. Rodning
    Pages 35-50
  5. Alfredo A. Santillan, Jeffrey M. Farma, Ramona Hagmaier, Charles E. Cox, Adam I. Riker
    Pages 51-104
  6. William J. Harb
    Pages 105-125
  7. Deborah A. Nagle, Vitaliy Poylin
    Pages 127-133
  8. James M. Church
    Pages 145-160
  9. W. Donald Buie, Anthony R. MacLean
    Pages 161-179
  10. Kathryn R. Brown, Lynn P. Parker
    Pages 181-196
  11. Back Matter
    Pages 197-204

About this book


The advances in our understanding of genetics has exploded since the publication of the first edition of Inherited Cancer Syndromes. We’ve moved from an incomplete understanding of the human genome to the availability of over-the-counter DNA analysis kits. There is simply too much complicated, high-level science for a busy clinician to meaningfully absorb without a filter. Inherited Cancer Syndromes is designed to bridge that gap. With this new edition, the clinical content has been expanded and clarified in order to be more tightly focused on the real-world implications of emerging therapies. The chapter authors are among the leading experts in these topics. Naturally, this book is not meant to be an exhaustive “how to” textbook or procedure-heavy monograph, but a clinically relevant overview of this dynamic and difficult aspect of cancer patient care. “ The chapters on syndromes are divided by type of cancer, and each includes discussions of risk assessment, indications for genetic testing, interpretation of test results, and integration into clinical management of risk estimates and results of genetic testing. The chapter on breast cancer also provides an insightful discussion of surrogate end-point markers. Each syndrome of susceptibility to polyposis and nonpolyposis colon cancer is described, with algorithms as to when genetic testing is indicated. Guidelines for prevention and management follow. … This book provides the knowledge base needed for most physicians to incorporate the principles of inherited susceptibility to cancer and genetic testing properly into their practices. It is highly recommended, since many physicians and health care workers have not been trained in this area, which has become an established part of clinical medicine.” Book Review, New England Journal of Medicine Volume 351:2137-2138 November 11, 2004 Number 20


Breast Cancer Cancer Colon Cancer Genetic Cancer Markers Inherited Cancer Syndromes Molecular Medicine Ovarian Cancer Surgical Oncology

Editors and affiliations

  • C. Neal Ellis
    • 1
  1. 1., Colon and Rectal SurgeryWest Penn Allegheny Health SystemPittsburghUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science + Business Media 2011
  • Publisher Name Springer, New York, NY
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-1-4419-6820-3
  • Online ISBN 978-1-4419-6821-0
  • Buy this book on publisher's site