Environmental Factors, Genes, and the Development of Human Cancers

  • Deodutta Roy
  • M. Tevfik Dorak

Table of contents

  1. Front Matter
    Pages i-xiii
  2. General Principles

  3. Environment and Specific Types of Cancer

    1. Front Matter
      Pages 221-221
    2. Brian Kunkle, David Sandberg, Prasanna Jayakar, Quentin Felty, Deodutta Roy
      Pages 223-252
    3. Esma Ucisik-Akkaya, M. Tevfik Dorak
      Pages 277-302
    4. Aruna S. Jaiswal, Melissa L. Armas, Shahnjayla K. Connors, Harekrushna Panda, Satya Narayan
      Pages 303-329
    5. Tuya Pal, Jenny Permuth Wey, Thomas A. Sellers
      Pages 367-398
  4. Case Studies

    1. Front Matter
      Pages 399-399
    2. Rajesh N. Sharan, Yashmin Choudhury
      Pages 401-428
    3. Nadia Barahmani, M. Fatih Okcu
      Pages 429-444
    4. Charronne F. Davis, M. Tevfik Dorak
      Pages 445-475
  5. Back Matter
    Pages 477-520

About this book


Cancer is a complex disease. Only 5-10% of human cancers are hereditary in nature. Many of us think of environmental agents when we think of carcinogens. The environment includes all that surrounds us, and environmental influences include not only chemical, physical and biological toxicants, but also diet and lifestyle. In this broadest sense, the environment contributes substantially in the development of human cancer. This book will describe how environment contributes to malignant transformation leading to profound changes in the genetic and signaling networks that control the functioning of the cell. It will critically discuss the understanding of the effects of environment on the development, progression and metastasis of cancer with current knowledge of the signaling networks that support functioning of transformed human cells. Genes and environmental factors that influence the origins of cancer are not necessarily the same as those that contribute to its progression and metastasis. Susceptibility gene variants for each specific cancer are being identified with emerging evidence of gene–environment interaction. Gene-environment interactions will be discussed through each specific cancer-based approach to address the question of how genetic variations can influence susceptibility to the individual type of cancer. It will also highlight and summarize epigenetic changes that increase the risk for susceptibility to a particular type of cancer, particularly in the presence of specific environmental factors. Thus, this book will contain chapters from the world’s experts focused on the current evidences that support the role of environment in the cancer etiology and in the growth of malignant lesions, and discuss who may be susceptible to environmental influences.


brain tumors cancer carcinogenesis cell liver metastasis mutagen ovarian cancer research

Editors and affiliations

  • Deodutta Roy
    • 1
  • M. Tevfik Dorak
    • 2
  1. 1.Robert Stempel School of Public Health, Dept. Environmental & Occupational HealtFlorida International UniversityMiamiUSA
  2. 2.Robert Stempel College of Public Health, Department of Environmental and OccupatiFlorida International UniversityMiamiUSA

Bibliographic information