Pre-Invasive Disease: Pathogenesis and Clinical Management

  • Rebecca C. Fitzgerald

Table of contents

  1. Front Matter
    Pages i-xxii
  2. Pathogenesis

  3. Model Systems and Clinical Approaches

    1. Front Matter
      Pages 129-129
    2. Robert D. Cardiff, Alexander D. Borowsky
      Pages 131-150
    3. Kareem M. Shariff, Pierre Lao-Sirieix
      Pages 151-166
    4. Scott K. Lyons, Kevin M. Brindle
      Pages 167-207
    5. Richard A. Hubner
      Pages 209-226
    6. Namasivayam Vikneswaran, Kenneth K. Wang
      Pages 227-244
    7. Robert N. Whistance, Shelley Potter, Mark Eveleigh, Jane M. Blazeby
      Pages 245-268
  4. Disease Specific Examples

    1. Front Matter
      Pages 269-269
    2. Ornella Belvedere, Anindo K. Banerjee, Pamela Rabbitts
      Pages 271-295
    3. Miriam P. Rosin, Catherine F. Poh, S. Y. Catherine Kang, Calum E. MacAulay, Lewei Zhang
      Pages 297-313
    4. Rebecca Fitzgerald
      Pages 315-340
    5. Elisa Cattaneo, Michael Baudis, Federico Buffoli, Maria Antonia Bianco, Fausto Zorzi, Giancarlo Marra
      Pages 369-394
    6. Hanno Matthaei, Anirban Maitra
      Pages 395-420
    7. John P. Brown, Sarah E. Pinder
      Pages 421-436
    8. Wen-Chung Chen, Barbara Ma, Chih-Ping Mao, T-C Wu
      Pages 437-466
    9. Alastair D. Lamb, Anne Y. Warren, David E. Neal
      Pages 467-491
  5. Common Threads

  6. Back Matter
    Pages 509-519

About this book


There are many books written on cancer, but this monograph focuses on pre-invasive disease. One of the prizes waiting to be won in cancer medicine is to thoroughly understand the processes by which a cell becomes invasive. This quest takes us into the world of stem cells and regulation of gene expression as well as to an understanding of the relative contribution of hereditary factors alongside exposures to environmental agents. This book explores these fundamental concepts as well as considering how advances in disease models combined with –omic technologies and molecular imaging might lead to advances in treatments such as chemoprevention and endoscopic treatments. The final section of the book takes nine specific examples of pre-invasive disease and explores the current state of knowledge and clinical practice as well as looking to the future. This book is written by International experts in their field and should appeal to students and seasoned researchers, to scientists and to clinicians. No prior knowledge of the topic is required to appreciate this text and yet the book charters new territory. New perspectives are given on how our knowledge of cancer development might lead us to reconsider our clinical approach to early detection and prevention of cancer at an individual and population level.

Editors and affiliations

  • Rebecca C. Fitzgerald
    • 1
  1. 1., MRC Cancer Cell UnitHutchison-MRC Research CentreCambridgeUnited Kingdom

Bibliographic information