The Physical Basis of Biochemistry

The Foundations of Molecular Biophysics

  • Peter R. Bergethon

Table of contents

  1. Front Matter
    Pages i-xxix
  2. Principles of Biophysical Inquiry

  3. Foundations

    1. Front Matter
      Pages 107-107
    2. Peter R. Bergethon
      Pages 109-123
    3. Peter R. Bergethon
      Pages 125-190
    4. Peter R. Bergethon
      Pages 191-242
    5. Peter R. Bergethon
      Pages 243-268
    6. Peter R. Bergethon
      Pages 293-326
    7. Peter R. Bergethon
      Pages 351-385
  4. Building a Model of Biomolecular Structure

    1. Front Matter
      Pages 387-387
    2. Peter R. Bergethon
      Pages 389-408
    3. Peter R. Bergethon
      Pages 409-439
    4. Peter R. Bergethon
      Pages 441-459

About this book


The Physical Basis of Biochemistry is an introduction to the philosophy and practice of an interdisciplinary field in which biological systems are explored using the quantitative perspective of the physical scientist. As with the first edition, the idea that a fundamental understanding of the basic physical principles underlying chemical biological systems is vital remains the focus of this second edition. This new edition of The Physical Basis of Biochemistry has substantial new material added with respect to models at the simple molecular level (including van der Waals gases and virial treatments) which is tied to coverage of models of polymer thermo-dynamics. The second edition is partitioned into five sections: the central concept that science is a way of looking at the world; the physical under-pinnings of biophysical chemistry with an emphasis first on energy, work and forces of biological importance; exploring how models applicable to molecular biophysics are constructed; the three-dimensional potential energy surface put into motion; and a succinct discussion of the bio-physical methods used to evaluate structure and function in biological systems. Additionally, a section of appendices continues to serve the pur¬pose of presenting some review information and certain topics in detail. The Physical Basis of Biochemistry will be of interest to quantitatively-oriented biologists as well as aspiring chemists, physicists, and engineers with an interest in biological systems.


Biophysics Proteomics Termination biochemistry bioinformatics cells microscopy thermodynamics

Authors and affiliations

  • Peter R. Bergethon
    • 1
  1. 1.School of Medicine, Dept. Anatomy & NeurobiologyBoston UniversityBostonUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC 2010
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-4419-6323-9
  • Online ISBN 978-1-4419-6324-6
  • About this book