Recent Advances on Model Hosts

  • Eleftherios Mylonakis
  • Frederick M. Ausubel
  • Michael Gilmore
  • Arturo Casadevall
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 710)

Table of contents

  1. Front Matter
    Pages i-vi
  2. Tomomi Komura, Takanori Ikeda, Kaori Hoshino, Ayumi Shibamura, Yoshikazu Nishikawa
    Pages 19-27
  3. Laurent Boyer, Nicholas Paquette, Neal Silverman, Lynda M. Stuart
    Pages 29-36
  4. Thomas Roeder, Kerstin Isermann, Kim Kallsen, Karin Uliczka, Christina Wagner
    Pages 37-47
  5. Isabella Vlisidou, Nicholas Waterfield, Will Wood
    Pages 49-57
  6. René Augustin, Sebastian Fraune, Sören Franzenburg, Thomas C. G. Bosch
    Pages 71-81
  7. Petr Kopacek, Ondrej Hajdusek, Veronika Buresova
    Pages 83-93
  8. Juliana Campos Junqueira
    Pages 95-105
  9. Back Matter
    Pages 135-136

About these proceedings

Introduction

Most studies of bacterial or fungal infectious diseases focus separately on the pathogenic microbe, the host response, or the characterization of therapeutic compounds. Compartmentalization of pathogenesis-related research into an analysis of the “pathogen”, the “host,” or the “antimicrobial compound” has largely been dictated by the lack of model systems in which all of these approaches can be used simultaneously, as well as by the traditional view that microbiology, immunology, and chemical biology and pharmacology are separate disciplines. An increasing number of workers from different fields have turned to insects, fish, worms and other model hosts as facile, ethically expedient, relatively simple, and inexpensive hosts to model a variety of human infectious diseases and to study host responses and innate immunity. Because many of these hosts are genetically tractable, they can be used in conjunction with an appropriate pathogen to facilitate the discovery of novel features of the host innate immune response.

This book provides a series of reports from the 1st International Conference on Model Hosts. This first of its kind meeting focused on invertebrate, vertebrate and amoeboid systems used for the study of host-pathogen interactions, virulence and immunity, as well as on the relevance of these pathogenesis systems and mammalian models. Importantly, a common, fundamental set of molecular mechanisms is employed by a significant number of microbial pathogens against a widely divergent array of metazoan hosts. Moreover, the evolutionarily conserved immune responses of these model hosts have contributed important insights to our understanding of the innate immune response of mammals.

Editors and affiliations

  • Eleftherios Mylonakis
    • 1
  • Frederick M. Ausubel
    • 2
  • Michael Gilmore
    • 3
  • Arturo Casadevall
    • 4
  1. 1.Massachusetts General HospitalHarvard Medical SchoolBostonUSA
  2. 2.Massachusetts General HospitalHarvard Medical SchoolBostonUSA
  3. 3.Schepens Eye Research Inst.Harvard Medical SchoolBostonUSA
  4. 4.Albert Einstein College of Medicine, Dept. Microbiology & ImmunologyYeshiva UniversityBronxUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4419-5638-5
  • Copyright Information Springer Science+Business Media, LLC 2012
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-4419-5637-8
  • Online ISBN 978-1-4419-5638-5
  • Series Print ISSN 0065-2598
  • About this book