The Rho GTPases in Cancer

  • Kenneth Golen

Table of contents

  1. Front Matter
    Pages i-xxii
  2. An Overview of the Rho GTPases

    1. Front Matter
      Pages 1-1
    2. Ellen V. Stevens, Channing J. Der
      Pages 3-27
    3. Devin T. Rosenthal, John Chadwick Brenner, Sofia D. Merajver
      Pages 29-42
  3. The Rho Regulatory Proteins in Cancer

    1. Front Matter
      Pages 44-44
    2. Anthony N. Anselmo, Gary M. Bokoch, Céline DerMardirossian
      Pages 45-58
    3. Nicole Hajicek, Barry Kreutz, Tohru Kozasa
      Pages 59-76
    4. Daniel D. Billadeau
      Pages 77-92
    5. Matthew W. Grogg, Yi Zheng
      Pages 93-107
  4. The Rho GTPase Proteins and Cancer

    1. Front Matter
      Pages 110-110
    2. Caroline McKinnon, Harry Mellor
      Pages 111-122
    3. Kenneth van Golen
      Pages 123-134
    4. Minzhou Huang, Lisa D. Laury-Kleintop, George C. Prendergast
      Pages 135-153
    5. Grant R Wickman, Michael S. Samuel, Pamela A Lochhead, Michael F Olson
      Pages 163-192
  5. Back Matter
    Pages 193-206

About this book


The Rho GTPases in Cancer is the first volume to collect and summarize the current understanding of the Rho GTPases and their involvement in the progression of human cancer. The critical role of the Rho GTPases, their regulatory proteins, and their effectors in cancer progression has become increasingly evident over the past decade. As translational research increases on these proteins, their importance as keystone molecules in vital cellular process is highlighted. Thus, these molecules represent a major class of potential therapeutic targets that could be exploited clinically. This aspect of Rho GTPase biology is developing, therefore the contents of The Rho GTPases in Cancer should prove of interest to clinicians and members of the cancer research community wishing to develop new treatments for cancer.


Activation GTPases Golen Migration Rho cancer physiology proteins regulation

Editors and affiliations

  • Kenneth Golen
    • 1
  1. 1.Dept. Biological SciencesUniversity of DelawareNewarkU.S.A.

Bibliographic information