Cellular Senescence and Tumor Suppression

  • Peter D. Adams
  • John M. Sedivy

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Senescence signals

    1. Front Matter
      Pages 1-1
    2. Laura Gardano, Lea Harrington
      Pages 3-43
    3. Avik Ghosh, Yie Liu, Vilhelm A. Bohr
      Pages 45-62
    4. Véronique Bourdeau, Gerardo Ferbeyre
      Pages 63-83
    5. Peter J. Hornsby
      Pages 85-106
  3. The senescent phenotype

    1. Front Matter
      Pages 108-108
    2. Gowrishankar Banumathy, Peter D. Adams
      Pages 109-123
    3. Hunter W. Richards, Estela E. Medrano
      Pages 125-174
    4. Vera Gorbunova, Andrei Seluanov
      Pages 175-197
  4. The physiological consequences of senescence

    1. Front Matter
      Pages 200-200
    2. Kodandaramireddy Nalapareddy, K. Lenhard Rudolph
      Pages 219-233
    3. Alan E. Bilsland, W. Nicol Keith
      Pages 235-265
  5. Back Matter
    Pages 267-272

About this book

Introduction

Leonard Hayflick and colleagues coined the term "cellular senescence" to describe the inevitable and irreversible proliferation arrest of primary human cells in culture. Specifically, Hayflick and coworkers reported the phenomenon of replicative senescence in primary human fibroblasts, showing that these cells can proliferate in vitro for about 55 population doublings before their proliferative capacity succumbs to irreversible proliferation arrest.

Since those original observations, major advances in our understanding have come in several areas. We now know that several other triggers, in addition to proliferative exhaustion, can trigger the senescence program. One important class of senescence triggers, and a focus of this volume, are activated oncogenes in primary untransformed cells. There is now good evidence to indicate that senescence in response to this cue is a potent tumor suppressor mechanism, through its ability to block proliferation of incipient cancer cells. However, senescence is not simply a passive proliferation arrest that impacts only the senescent cell itself, but rather, senescent cells influence their environment and neighboring cells through an active secretory program. This secretory program appears to facilitate senescence as a tumor suppression process.

Cellular Senescence and Tumor Suppression collects a number of chapters from leaders in the field to review the molecular basis of senescence and its physiological functions, with a particular emphasis on the role of senescence in tumor suppression.

Keywords

DNA Telomere aging biochemistry biology cancer cell chemistry development oncogene oncogenes proliferation senescence tissue tumor

Editors and affiliations

  • Peter D. Adams
    • 1
  • John M. Sedivy
    • 2
  1. 1.Cancer Research UKUniversity of GlasgowGlasgowUnited Kingdom
  2. 2.Dept. Molecular & Cell Biology &Brown UniversityProvidenceU.S.A.

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4419-1075-2
  • Copyright Information Springer-Verlag New York 2010
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-4419-1074-5
  • Online ISBN 978-1-4419-1075-2
  • About this book