Evidence Based Pathology and Laboratory Medicine

  • Alberto M. Marchevsky
  • Mark Wick

Table of contents

  1. Front Matter
    Pages i-xiv
  2. The Problem and Available Resources

  3. Solutions Offered by Evidence-Based Pathology and Laboratory Medicine

    1. Front Matter
      Pages 187-187
    2. Kenneth A. Fleming, Kenneth A. Fleming
      Pages 203-211
    3. Ruta Gupta, Alberto M. Marchevsky
      Pages 245-259
    4. Mark R. Wick, Paul E. Swanson, Alberto M. Marchevsky
      Pages 261-295
    5. Stacy E. F. Melanson, Aileen P. Morrison, David W. Bates, Milenko J. Tanasijevic
      Pages 323-335
    6. Mark R. Wick, Elliott Foucar
      Pages 337-348
  4. Back Matter
    Pages 349-361

About this book


Focusing on practical, patient related issues, this volume provides the basic concepts of Evidence Based Medicine (EBM) as they relate to Pathology and Laboratory Medicine and presents various practical applications. It includes EBM concepts for use in the identification of cost-effective panels of immunostains and other laboratory tests and for improvement of diagnostic accuracy based on the identification of selected diagnostic features for particular differential diagnosis. EBM concepts are also put forth for use in Meta-analysis to integrate the results of conflicting literature reports and use of novel analytical tools such as Bayesian belief networks, neural networks, multivariate statistics and decision tree analysis for the development of new diagnostic and prognostic models for the evaluation of patients. This volume will be of great value to pathologists who will benefit from the concepts being promoted by EBM, such as levels of evidence, use of Bayesian statistics to develop diagnostic and other rules and stronger reliance on "hard data" to support therapeutic and diagnostic modalities.


Bayesian statistics Immunostains Laboratory tests Meta-analysis Neural networks

Editors and affiliations

  • Alberto M. Marchevsky
    • 1
  • Mark Wick
    • 2
  1. 1.Dept. Pathology & Laboratory MedicineCedars-Sinai Medical CenterLos AngelesUSA
  2. 2.Medical Center, Dept. PathologyUniversity of VirginiaCharlottesvilleUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC 2011
  • Publisher Name Springer, New York, NY
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-1-4419-1029-5
  • Online ISBN 978-1-4419-1030-1
  • Buy this book on publisher's site