Lung Cancer Metastasis

Novel Biological Mechanisms and Impact on Clinical Practice

  • Venkateshwar Keshamouni
  • Douglas Arenberg
  • Gregory Kalemkerian

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Shirish M. Gadgeel, Gregory P. Kalemkerian
    Pages 1-27
  3. M. Roshni Ray, David M. Jablons
    Pages 29-46
  4. Jaclyn Y. Hung
    Pages 47-63
  5. Katia Savary, Stefan Termén, Sylvie Thuault, Venkateshwar Keshamouni, Aristidis Moustakas
    Pages 65-92
  6. Charles Kumar Thodeti, Kaustabh Ghosh
    Pages 93-109
  7. Jay M. Lee, Jane Yanagawa, Saswati Hazra, Sherven Sharma, Tonya Walser, Edward Garon et al.
    Pages 111-134
  8. Borna Mehrad, Ellen C. Keeley, Robert M. Strieter
    Pages 155-172
  9. Mark M. Fuster, Judith A. Varner
    Pages 173-191
  10. Roya Navab, Bizhan Bandarchi, Ming-Sound Tsao
    Pages 193-215
  11. Zvi G. Fridlender, M. Cecilia Crisanti, Steven M. Albelda
    Pages 217-239
  12. Jiang Liu, Michael R. Johnston
    Pages 241-265
  13. Mahaveer Swaroop Bhojani, Shyam Nyati, Hyma R. Rao, Brian D. Ross, Alnawaz Rehemtulla
    Pages 267-287
  14. Gilbert S. Omenn, James D. Cavalcoli
    Pages 289-315
  15. Bryan J. Schneider, Suresh S. Ramalingam
    Pages 317-350
  16. Kevin S Oh, Baskaran Sundaram, Venkataramu Krishnamurthy, Allan Pickens, Malini Venkatram, Ella A Kazerooni et al.
    Pages 351-381
  17. Peter J. Woolf, Angel Alvarez, Venkateshwar G. Keshamouni
    Pages 383-394
  18. Back Matter
    Pages 395-409

About this book

Introduction

Lung cancer is the leading cause of cancer related mortality. Metastatic lung cancer is responsible for more than ninety percent of lung cancer related deaths. However, relatively little progress has been made in understanding the process of lung cancer metastasis. The two main aims of this book are a) to introduce clinical aspects to basic scientists and basic molecular and cellular concepts to clinical investigators, in order to promote collaboration and foster much needed translational research; and b) to introduce new and emerging concepts and approaches in metastasis research to lung cancer research community at large. In this attempt, the book will cover a broad spectrum of subjects ranging from the current trends in the clinical management of the metastatic disease, to the systems biology approach for gaining insights into the mechanisms of metastasis. Some of the subjects covered will include: defining basic hallmarks of a metastatic cell, the concept of tumor stem cells, epithelial-mesenchymal transitions, evasion of immune-surveillance, tumor-stromal interactions, angiogenesis, molecular imaging and biomarker discovery.

The primary audience for this book are physicians involved in the management of lung cancer in the clinic, clinical investigators and basic scientists focused on lung cancer research, cancer biologists investigating mechanisms of metastasis, pharmaceutical and biotechnology industry professionals with an interest in development of metastasis-targeted diagnostics and therapeutics, and graduate students and postdoctoral fellows in cancer biology programs.

Keywords

angiogenesis carcinogenesis carcinoma cell imaging macrophages metastasis metastatic disease mortality tumor

Editors and affiliations

  • Venkateshwar Keshamouni
    • 1
  • Douglas Arenberg
    • 2
  • Gregory Kalemkerian
    • 3
  1. 1.Dept. Internal MedicineUniversity of Michigan Health SystemAnn ArborU.S.A.
  2. 2.Dept. Internal MedicineUniversity of MichiganAnn ArborU.S.A.
  3. 3.Dept. Internal MedicineUniversity of MichiganAnn ArborU.S.A.

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4419-0772-1
  • Copyright Information Springer-Verlag New York 2010
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-4419-0771-4
  • Online ISBN 978-1-4419-0772-1
  • About this book