Cancer Genome and Tumor Microenvironment

  • Andrei Thomas-Tikhonenko

Part of the Cancer Genetics book series (CANGENETICS)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Opening Remarks

    1. Front Matter
      Pages 1-1
    2. Andrei Thomas-Tikhonenko
      Pages 3-8
  3. Breaking Away: Epithelial-Mesenchymal Transition

  4. Coming up for Air: Hypoxia and Angiogenesis

    1. Front Matter
      Pages 117-117
    2. Prema Sundaram, Chi V. Dang, Andrei Thomas-Tikhonenko
      Pages 167-187
    3. Jose G. Teodoro, Sara K. Evans, Michael R. Green
      Pages 189-216
    4. Greg H. Enders
      Pages 217-229
  5. Gaining New Ground: Metastasis and Stromal Cell Interactions

    1. Front Matter
      Pages 231-231
    2. Rajeev Kaul, Masanao Murakami, Pankaj Kumar, Erle S. Robertson
      Pages 233-271
    3. Mandira Ray, J G Garcia, Ravi Salgia
      Pages 273-292
    4. Antoni Xavier Torres-Collado, M. Luisa Iruela-Arispe
      Pages 293-314
    5. Michele Jacob, Ellen Puré
      Pages 315-333
    6. Qinghua Zeng, Boris Pasche
      Pages 335-348

About this book

Introduction

Oncogenes and tumor suppressor genes had been traditionally studied in the context of cell proliferation, differentiation, senescence, and survival, four relatively cell-autonomous processes. Consequently, in the late ‘80s-mid ‘90s, neoplastic growth was described largely as a net imbalance between cell accumulation and loss, brought about through mutations in cancer genes. In the last ten years, a more holistic understanding of cancer slowly emerged, stressing the importance of interactions between neoplastic and various stromal components: extracellular matrix, basement membranes, fibroblasts, endothelial cells of blood and lymphatic vessels, tumor-infiltrating lymphocytes, etc . Nevertheless, the commonly held view is that changes in tumor microenvironment are "soft-wired", i.e. epigenetic in nature and often reversible. Yet, there exists a large body of evidence suggesting that well-known mutations in cancer genes profoundly affect tumor milieu. In fact, these cell-extrinsic changes might be one of the primary reasons such mutations are preserved in late-stage tumors. Cancer Genome and Tumor Microenvironment reviews how tumor microenvironment and progression can be "hard-wired", i.e. genetically controlled.

Keywords

Chromosom angiogenesis cell genes lymphocytes lymphoma melanoma metastasis senescence tumor tumor progression

Editors and affiliations

  • Andrei Thomas-Tikhonenko
    • 1
  1. 1.Children's Hospital of PhiladelphiaPhiladelphiaU.S.A.

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4419-0711-0
  • Copyright Information Springer-Verlag New York 2010
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-4419-0710-3
  • Online ISBN 978-1-4419-0711-0
  • About this book