Epigenetics of Aging

  • Trygve O. Tollefsbol

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Epigenetics and the Aging Process

    1. Front Matter
      Pages 1-1
    2. Trygve O. Tollefsbol
      Pages 1-8
    3. Igor P. Pogribny, Boris F. Vanyushin
      Pages 11-27
  3. DNA Methylation and Histone Modifications in Aging

    1. Front Matter
      Pages 9-9
    2. Adebayo D. Akintola, Alan R. Parrish
      Pages 29-39
  4. DNA Methylation and Histone Modifications in Aging

    1. Yuqing Dong, Sige Zou
      Pages 51-75
  5. DNA Methylation and Histone Modifications in Aging

  6. Other Epigenetic Processes and Aging

    1. Front Matter
      Pages 133-133
    2. Krishnaveni Mishra, Rakesh K. Mishra
      Pages 135-150
    3. Eric Gilson, Frédérique Magdinier
      Pages 151-175
  7. Impact of Epigenetics on Aging

    1. Front Matter
      Pages 189-189
    2. Huaping Chen, Trygve O. Tollefsbol
      Pages 191-204
    3. J. Arturo Londoño-Vallejo
      Pages 205-225
  8. Impact of Epigenetics on Aging

    1. Pinaki Bose, Amudha Ganapathy, Karl Riabowol
      Pages 227-255
  9. Impact of Epigenetics on Aging

    1. Ester Lara*, Vincenzo Calvanese*, Mario F. Fraga
      Pages 257-273
    2. J. Tyson DeAngelis, Trygve O. Tollefsbol
      Pages 275-281
  10. Epigenetics of Age-Related Diseases

    1. Front Matter
      Pages 283-283
    2. Kristen H. Taylor, Lynda B. Bennett, Gerald L. Arthur, Huidong Shi, Charles W. Caldwell
      Pages 285-313
    3. Thomas van Groen
      Pages 315-326
  11. Epigenetics of Age-related Diseases

    1. Jörg J. Goronzy, Guangjin Li, Cornelia M. Weyand
      Pages 327-344
    2. Ruben Agrelo
      Pages 345-369
    3. Helmtrud I. Roach
      Pages 371-391
  12. Epigenetic Interventions and Aging

    1. Front Matter
      Pages 393-393
    2. Ulrich Mahlknecht, Barbara Zschoernig
      Pages 395-406
    3. Trygve O. Tollefsbol, Yuanyuan Li
      Pages 407-416
  13. Epigenetic Interventions and Aging

    1. Sabita N. Saldanha, Ashley McCollum, Trygve O. Tollefsbol
      Pages 417-429
  14. Future Directions/Perspectives

    1. Front Matter
      Pages 431-431
    2. Charles W. Caldwell, Huidong Shi
      Pages 433-446
    3. Robin Holliday
      Pages 447-455
  15. Back Matter
    Pages 457-469

About this book


Revealing the molecular basis of aging has been one of the most challenging aspects of medical science, and now the epigenetics of aging is in a Renaissance phase. This seminal work covers the fascinating role of epigenetics in aging, ranging from basic epigenetic processes of aging to epigenetic drugs that may intervene in allow aging and age-related diseases.

Epigenetics of Aging presents in-depth analyses of DNA methylation, histone modifications, RNA alterations, and chromosomal defects that impact the aging process. It also includes detailed essays describing the impact of epigenetics on aging, the epigenetics of age-related diseases, and future directions and perspectives on the epigenetics of aging.

With chapters authored by leading researchers in the field, this seminal book on the epigenetics of aging:

-Ranges from basic science to clinical practice

-Describes the importance of epigenetics in numerous diseases of aging such as cancer, Alzheimer’s disease, immune defects, and osteoporosis

-Includes the role of epigenetics in premature aging diseases such as progeria

-Highlights emerging aspects of epigenetics in aging, such as polycomb group genes and noncoding RNAs

-Covers sirtuins, chromatin alterations, and the role of epigenetic drift in aging

-Describes the impact of the environment and diet in modulating epigenetic processes during aging

Epigenetics of Aging is the first book in this exponentially expanding field, and will be an indispensable source of information for those with interests in epigenetics and/or aging. This authoritative core textbook for advanced students or medical scientists and practitioners details the fascinating and revolutionary field of the epigenetics of aging and covers the most recent advances that impact the longevity of living organisms.


Chromosom DNA Telomere aging genetics senescence

Editors and affiliations

  • Trygve O. Tollefsbol
    • 1
  1. 1.Department of BiologyUniversity of Alabama at BirminghamBirminghamUSA

Bibliographic information