Macromolecular Anticancer Therapeutics

  • L. Harivardhan Reddy
  • Patrick Couvreur

Part of the Macromolecular Anticancer Therapeutics book series (CDD&D)

Table of contents

  1. Front Matter
    Pages i-xx
  2. Classification, Opportunities and Challenges

    1. Front Matter
      Pages 1-1
    2. Enrique Espinosa, César Gómez Raposo
      Pages 3-35
    3. Michele Milella, Ludovica Ciuffreda, Emilio Bria
      Pages 37-83
  3. Polymer-Based Anticancer Prodrugs

    1. Front Matter
      Pages 85-85
    2. B. Rihova, O. Hovorka, L. Kovar, M. Kovar, T. Mrkvan, M. Sirova et al.
      Pages 87-132
    3. Jack W. Singer, Marc McKennon, Gabriella Pezzoni, Stefano di Giovine, Mara Cassin, Paola de Feudis et al.
      Pages 133-161
    4. Paolo Caliceti, Stefano Salmaso, Sara Bersani
      Pages 163-219
    5. Francesca Cateni, Marina Zacchigna
      Pages 221-263
    6. F.M. Veronese, G. Pasut, S. Drioli, G.M. Bonora
      Pages 265-288
  4. Lipid-Based Anticancer Prodrugs

    1. Front Matter
      Pages 287-287
    2. L. Harivardhan Reddy, Patrick Couvreur
      Pages 291-328
  5. Antibody-Directed Cancer Therapy

    1. Front Matter
      Pages 327-327
    2. Carol A. Vater, Victor S. Goldmacher
      Pages 331-369
    3. Serengulam V. Govindan, David M. Goldenberg
      Pages 371-392
    4. Surinder K. Sharma, Kenneth D. Bagshawe
      Pages 393-406
    5. Roberto Bianco, Teresa Gelardi, Sonia Garofalo, Roberta Rosa, Giampaolo Tortora
      Pages 407-436
    6. Jennifer K. Litton, Gabriel N. Hortobagyi
      Pages 437-464
    7. Ernest S. Han, Bradley J. Monk
      Pages 465-491
    8. Kenneth A. Foon, Michael Boyiadzis, Samuel A. Jacobs
      Pages 493-536
  6. Anticancer Oligonucleotide Therapeutics

    1. Front Matter
      Pages 534-534
    2. Anne Laure Ramon, Claude Malvy
      Pages 539-568
  7. Miscellaneous

    1. Front Matter
      Pages 567-567
    2. Véronique Marsaud, Jack-Michel Renoir
      Pages 571-611
  8. Back Matter
    Pages 613-623

About this book


The field of macromolecular therapeutics for cancer therapy is of considerable importance, as these therapeutic systems are gaining more and more interest to give new directions for the treatment of this dreadful disease. Macromolecular Anticancer Therapeutics, which describes in detail the macromolecular therapeutics for cancer therapy, covers the classification of these anticancer drugs based on therapeutic targets, and elaborates on different classes of anticancer therapeutics which are either in pre-clinic or in clinical phases or are already commercialized. This book also discusses various signal transduction pathways involved in the cancer growth and resistance to therapy, providing a clear insight into the molecular mechanistic aspects of this topic; it also describes the essential targets for efficient cancer therapy. In detail, this volume elaborates the different categories of macromolecular therapeutics of respectively natural and synthetic polymer and lipid origin, their chemistry, design and development, opportunities and challenges, current status, pre-clinic and clinical progresses. In addition, the design, development, and the challenges involved in future directions for cancer therapy using various categories of antibody-based therapeutics are elaborated in areas such as antibody-mediated drug targeting to cancer employing antibody-drug conjugates, radioimmunoconjugates, toxin-antibody conjugates, antibody-mediated enzyme pro-drug therapeutics, and also using antibodies alone to interfere with specific molecular targets responsible for tumor growth and progression. Besides the current status, pre-clinic and clinical progress of a variety of therapeutic anticancer oligonucleotides and siRNA designed and developed for specific inhibition of oncogenes are detailed. Furthermore, in this book, special attention is given to the treatment of breast cancer based on a comprehensive description about molecular mechanisms involved, hormone receptors implicated and molecular therapeutic interventions.

Macromolecular Anticancer Therapeutics details the current macromolecular therapeutic strategies, and should become an important reference for practitioners, oncologists, medical pharmacologists, medicinal chemists, biomedical scientists, experimental pharmacologists and pharmaceutical technologists. It is also a reference concerning macromolecular cancer therapy for graduates, post-graduates and Ph.D. students belonging to these fields.


cancer cancer therapy cancer treatment chemistry classification drug hormones imaging immunotherapy oncogene pharmacology research toxicity tumor vaccine

Editors and affiliations

  • L. Harivardhan Reddy
    • 1
  • Patrick Couvreur
    • 2
  1. 1.Faculte deUniversite Paris-Sud XIChatenay-Malabry cedexFrance
  2. 2.CNRS - UMR 8612Université de Paris XIChâtenay-MalabryFrance

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag New York 2010
  • Publisher Name Springer, New York, NY
  • eBook Packages Medicine
  • Print ISBN 978-1-4419-0506-2
  • Online ISBN 978-1-4419-0507-9
  • Buy this book on publisher's site